Evidence map›Paper›PMID 41629293›Full record

ArticleNature communications2026

PRMT3-mediated post-translational adaptation to fasting regulates metabolic flexibility.

Zhengyun Huang, Xiangpeng Liu, Xiyue Chen, You Zhou, Qian Chen, Yan Liu, Hongyun Zhu, Ken Cheng, Yu Feng, Miren Dong and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Zhengyun HuangCambridge-Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, China.
Xiangpeng LiuCambridge-Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, China.
Xiyue ChenDepartment of Animal Sciences, Purdue University, West Lafayette, IN, USA.
You ZhouCambridge-Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, China.
Qian ChenCambridge-Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, China.
Yan LiuDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0001-6358-4056
Hongyun ZhuWisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China.
Ken ChengWisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China.ORCID 0000-0003-3910-0220
Yu FengDepartment of Rheumatology and Immunology, The Forth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, Suzhou, China.ORCID 0000-0003-0034-6397
Miren DongLiaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian, China.
Linsheng SongLiaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian, China.ORCID 0000-0002-3580-6560
Lingling WangLiaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian, China.ORCID 0000-0002-1049-9170
Shiqi LiuCollege of Animal Sciences, Zhejiang University, Hangzhou, China.
Tizhong ShanCollege of Animal Sciences, Zhejiang University, Hangzhou, China.ORCID 0000-0002-4738-414X
Shihuan KuangDepartment of Orthopedic Surgery and Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-9180-3180
Yingying DongCambridge-Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, China.
Antonio Vidal-PuigUniversity of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC, Addenbrooke's Hospital, Cambridge, UK. ajv22@medschl.cam.ac.uk.ORCID 0000-0003-4220-9577
Yong ZhangCambridge-Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, China. yong.zhang@suda.edu.cn.ORCID 0000-0002-0936-9264
Zhihao JiaCambridge-Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, China. zhjia@suda.edu.cn.ORCID 0000-0001-5525-2721

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32100944
6 · The paper itself

Abstract

Obesity impairs metabolic flexibility-the capacity to adapt to fluctuating energy demands. Emerging evidence suggests that dietary interventions, particularly time-restricted feeding (TRF), may help restore this flexibility. In this study, we demonstrate that feeding upregulates PRMT3 and asymmetric dimethylarginine (ADMA)-containing proteins via insulin-pAKT signaling, while fasting reduces their expression. Pharmacological inhibition of PRMT3 attenuates diet-induced obesity (DIO) and enhances adipocyte glycolysis in male mice. Mechanistically, PRMT3 drives the expression of citrate transporter SLC25A1 during feeding through direct arginine methylation. A 16:8 TRF regimen normalizes PRMT3 and ADMA levels while suppressing SLC25A1 expression. Notably, PRMT3 inhibition recapitulates the metabolic benefits of 16:8 TRF and improves metabolic flexibility. Furthermore, adipocyte-specific deletion of Slc25a1 in male mice protects against DIO and enhances insulin sensitivity. Collectively, these findings identify PRMT3-mediated arginine methylation in vWAT as a nutrient-responsive regulatory axis that impairs metabolic flexibility in obesity, which is a potential therapeutic target.

Indexed as

FastingObesityProtein-Arginine N-MethyltransferasesProtein Processing, Post-TranslationalAdaptation, PhysiologicalAdipocytesAnimalsArginineDiet, High-FatHumansInsulinInsulin ResistanceIntermittent FastingMaleMethylationMiceArginineInsulinN,N-dimethylarginineProtein-Arginine N-Methyltransferases

Identifiers

PMID41629293
PMCPMC12966397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.