Evidence map›Paper›PMID 41629166›Full record

ArticleeNeuro2026

The Single-Prolonged Stress Model Fails to Produce Behavioral or Corticosterone Alterations in Rats.

Moriah McGuier, Elise Bragg, Paul Holtzheimer, Wilder Doucette

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Moriah McGuierDepartment of Psychiatry, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03766 moriah.mcguier@gmail.com.
Elise BraggDepartment of Psychiatry, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03766.
Paul HoltzheimerNational Center for PTSD, White River Junction Veteran Affairs Medical Center, White River Junction, Vermont 05001.
Wilder DoucetteDepartment of Psychiatry, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03766.ORCID 0000-0003-2249-0461

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a critical need for robust and reliable preclinical models for posttraumatic stress disorder (PTSD) to better understand pathophysiological mechanisms and support the development of novel treatments. The single prolonged stress (SPS) model has been previously utilized to investigate various acute behavioral effects and stress hormone changes in rodents. This study paired anxiety-like and social behavioral evaluations with corticosterone assessment as a complementary physiological biomarker to determine the presence of robust and intervenable phenotypes following SPS. Sprague Dawley rats (

Indexed as

Behavior, AnimalCorticosteroneDisease Models, AnimalSocial BehaviorStress Disorders, Post-TraumaticStress, PsychologicalAnimalsAnxietyFemaleMaleRatsRats, Sprague-DawleyCorticosteroneanxiety-like behaviorcorticosteroneHPA axisratsingle prolonged stress modelsocial behavior

Identifiers

PMID41629166
PMCPMC12870986

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.