ArticleNano letters2026
Nanopore-Based, Real-Time Single-Molecule Probing of i-Motif Structural Dynamics and Targeted PNA Disruption.
Article in Nano letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
The i-motif, a crucial noncanonical DNA structure, is prevalent in gene regulatory regions, yet its dynamics is challenging to probe. Here, we employ a wild-type α-hemolysin nanopore (α-HL) to sense the folding of a human telomeric i-motif. We demonstrate two distinct sensing paradigms: reversible i-motif collisions at the nanopore's β-barrel, producing transient current signatures, versus vestibule-first entry, yielding quasi-permanent blockades. The collision mode enables continuous i-motif dynamics monitoring, while vestibule entrapment provides ground for resolving pH-dependent volumetric changes in nanoconfinement with ∼nm
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