Evidence map›Paper›PMID 41628392›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2026

Diminishing Returns Among Black Patients With Cancer: The Intersection of Race and Neighborhood Socioeconomic Status.

Lauren E McCullough, Lauren E Barber, Rebecca Nash, Lindsay J Collin, Maret L Maliniak

Abstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lauren E McCulloughDepartment of Epidemiology, Emory University, Atlanta, GA.ORCID 0000-0001-6723-9540
Lauren E BarberDepartment of Epidemiology, Emory University, Atlanta, GA.ORCID 0000-0001-7321-6003
Rebecca NashDepartment of Epidemiology, Emory University, Atlanta, GA.ORCID 0000-0002-0499-2663
Lindsay J CollinDepartment of Epidemiology, Emory University, Atlanta, GA.ORCID 0000-0003-0170-2592
Maret L MaliniakDepartment of Epidemiology, Emory University, Atlanta, GA.ORCID 0000-0002-0763-5231

Funding

Improving our understanding of breast cancer mortality disparities through recurrence: a multi-level approach among women in GeorgiaR01CA259192 · NCI · EMORY UNIVERSITY · PI MCCULLOUGH, LAUREN E · 2021 to 2025
$2.9M
Identifying factors associated with ovarian cancer recurrence using a population-based approachR00CA277580 · NCI · EMORY UNIVERSITY · PI Lindsay Jane Collin · 2025 to 2026
$457k
NCI NIH HHS R00 CA277580NCI NIH HHS R01 CA259192
6 · The paper itself

Abstract

purposeDespite narrowing racial gaps, disparities persist across cancer types and socioeconomic levels. The diminishing returns hypothesis suggests that economic advantage yields fewer health benefits for Black individuals but is largely unexplored in the context of cancer. We examined the diminishing returns among Black and White individuals across cancer types using a nationally representative study population.

methodsThe study analyzed cancer-specific survival among 5.3 million non-Hispanic Black and White adults diagnosed with primary cancer (2006-2020) using SEER-22. We assessed how race and neighborhood socioeconomic status (SES) jointly affects survival across 21 cancer types. A 10-level race-SES variable was created, using White individuals in the highest-SES group as the reference. The main outcome was cancer-specific death. Diminishing returns were defined quantitively and qualitatively as worse survival for Black individuals even at higher SES. Cox models adjusted for demographics and clinical factors, with multiple imputation for missing data. Social gradients were also evaluated.

resultsBlack women showed strong evidence of diminishing returns overall and for seven cancers, especially uterine and breast cancers. A social gradient was also evident in cancers with diminishing returns, except uterine cancer. For Black men, diminishing returns were not observed across all cancers combined but was present in eight cancers-including prostate and colorectal cancers. Most cancers among men exhibited a strong social gradient. Findings were consistent by time period and upon restricting to localized and regional disease in sensitivity analyses.

conclusionHigher SES improves cancer survival for White patients but not Black patients, worsening racial disparities for certain cancers.

Indexed as

Black or African AmericanNeighborhood CharacteristicsNeoplasmsSocial ClassAdultAgedFemaleHumansMaleMiddle AgedResidence CharacteristicsSEER ProgramSocioeconomic Disparities in HealthUnited StatesWhite

Identifiers

PMID41628392
PMCPMC12922702

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.