Evidence map›Paper›PMID 41628333›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers.

Salomon Tendler, Roberto De Gregorio, Paul Balderes, Alexa L Michel, Tran T Hoang, David Bauer, Kathryn M Tully, Joshua A Korsen, Ivo C Lorenz, Abdul G Khan and 9 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. The Five-Decade Journey of Small Cell Lung Cancer.Cancer communications (London, England) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Salomon TendlerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-9058-0982
Roberto De GregorioDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Paul BalderesTri-Institutional Therapeutics Discovery Institute, New York, NY 10065.
Alexa L MichelDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Tran T HoangDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
David BauerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0002-3051-7997
Kathryn M TullyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Joshua A KorsenDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Ivo C LorenzTri-Institutional Therapeutics Discovery Institute, New York, NY 10065.
Abdul G KhanTri-Institutional Therapeutics Discovery Institute, New York, NY 10065.
Lukas CarterDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0003-4848-4190
Olivia VergnolleTri-Institutional Therapeutics Discovery Institute, New York, NY 10065.
Irina V LebedevaTri-Institutional Therapeutics Discovery Institute, New York, NY 10065.ORCID 0000-0002-1693-9392
Elisabeth K NyakaturaTri-Institutional Therapeutics Discovery Institute, New York, NY 10065.
Lisa BodeiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-6930-7383
Michael J MorrisDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0002-9454-0096
John T Poirier *Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Charles M Rudin *Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-5204-3465
Jason S Lewis *Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-7065-4534

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Coordinating center for the NCI small cell lung cancer research consortiumU24CA213274 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Lauren Averett Byers, JOHN D. MINNA · 2017 to 2026
$12.9M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Novel therapeutic development for small cell lung cancerR35CA263816 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Charles M. Rudin · 2021 to 2026
$6.3M
Immuno-PET imaging of high-grade neuroendocrine lung tumors using 89Zrrovalpituzumab, a DLL3-targeting monoclonal antibodyR01CA213448 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI POIRIER, JOHN THOMAS, RUDIN, CHARLES M. · 2017 to 2021
$3.1M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA213448NCI NIH HHS R35 CA232130NCI NIH HHS R35 CA263816NCI NIH HHS U24 CA213274
6 · The paper itself

Abstract

Delta-like ligand 3 (DLL3) is a tumor-selective cell surface protein upregulated in high-grade neuroendocrine tumors, including small-cell lung cancer (SCLC) and neuroendocrine prostate cancer (NEPC). Here, we report on the development of anti-DLL3 radioimmunoconjugates for use as either a diagnostic imaging tracer based on the positron-emitter zirconium-89 (

Indexed as

Lung NeoplasmsMembrane ProteinsNeuroendocrine TumorsProstatic NeoplasmsRadiopharmaceuticalsSmall Cell Lung CarcinomaAnimalsAntibodies, MonoclonalCell Line, TumorFemaleHumansImmunoconjugatesIntracellular Signaling Peptides and ProteinsLutetiumMaleMiceAntibodies, MonoclonalDLL3 protein, humanImmunoconjugatesIntracellular Signaling Peptides and ProteinsLutetiumLutetium-177Membrane ProteinsRadioisotopesRadiopharmaceuticalsZirconiumZirconium-89DLL3Lutetium-177NEPCSCLCTheranostics

Identifiers

PMID41628333
PMCPMC12890834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.