ArticleProceedings of the National Academy of Sciences of the United States of America2026
Neuron-specific modulation of SLC30A10 identifies dopaminergic and glutamatergic neurons as targets of manganese-induced motor disease.
Stephanie M Grant, Ashvini Melkote, Mollie X Bernstein, Thomas Jursa, Cherish A Taylor, Steven Hutchens, William Shawlot, Larry S Zweifel, Rueben A Gonzales, Donald R Smith and 1 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Stephanie M Grant *Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712.
Ashvini Melkote *Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712.ORCID 0009-0005-8728-8813 Thomas JursaDepartment of Microbiology and Environmental Toxicology, University of California at Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0002-7264-904X Cherish A TaylorDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712.
Steven HutchensDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712.
William ShawlotMouse Genetic Engineering Facility, Center for Biomedical Research Support, University of Texas at Austin, Austin, TX 78712.ORCID 0009-0008-3539-7366 Rueben A GonzalesDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712.
Donald R SmithDepartment of Microbiology and Environmental Toxicology, University of California at Santa Cruz, Santa Cruz, CA 95064.
Somshuvra MukhopadhyayDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712.ORCID 0000-0002-3420-7830 Funding
Regulation of manganese homeostasis and detoxification by SLC30A10R01ES024812 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI Somshuvra Mukhopadhyay · 2016 to 2026
$5.7MRole and mechanisms of excretion in manganese neurotoxicityR01ES031574 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI MUKHOPADHYAY, SOMSHUVRA · 2020 to 2025
$3.5MIdentifying neuronal targets and mechanisms of manganese-induced neuromotor diseaseF31ES036908 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI MELKOTE, ASHVINI · 2024 to 2025
$82kHHS | NIH | National Institute of Environmental Health Sciences (DEHS) F31-ES036908NIEHS NIH HHS F31 ES036908NIEHS NIH HHS R01 ES024812NIEHS NIH HHS R01 ES031574
6 · The paper itselfAbstract
Essential metals accumulate in the basal ganglia at elevated levels and induce incurable motor disease. But, unlike other motor diseases, the neuronal targets of essential metals are unknown, and this fundamental knowledge gap has limited therapeutic progress. Because metal efflux transporters have high specificity, we hypothesized that neuron-specific knockout or knockin (i.e., overexpression) of efflux transporters may alter metal levels in targeted neurons and define the neuronal targets of metal-induced disease. To test this, we focused on manganese (Mn)-induced motor disease, which is a public health problem. We generated six neuron-specific
Indexed as
Cation Transport ProteinsDopaminergic NeuronsManganeseMotor DisordersNeuronsAnimalsGlutamic AcidMiceMice, KnockoutCation Transport ProteinsGlutamic AcidManganesebasal gangliamanganesemetal homeostasismetal transporterparkinsonism
Identifiers
PMID41628331
PMCPMC12890882
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