Evidence map›Paper›PMID 41628197›Full record

ArticleThe Journal of antimicrobial chemotherapy2026

The effect of oral ciprofloxacin at conventional doses on the QT interval in a tertiary outpatient setting.

Weber Liu, Hugh G Dickson, Hany Dimitri, Yashodha Shankar Pani, Jayanathi Ramanathan, Dana West, Sarah Tima, Winston Thai

Abstract read
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In one paragraph

Article in The Journal of antimicrobial chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Weber LiuSchool of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-2156-3473
Hugh G DicksonFaculty of Medicine and Health, The University of New South Wales, Sydney, NSW 2052, Australia.
Hany DimitriFaculty of Medicine and Health, The University of New South Wales, Sydney, NSW 2052, Australia.
Yashodha Shankar PaniFaculty of Medicine and Health, The University of New South Wales, Sydney, NSW 2052, Australia.
Jayanathi RamanathanFaculty of Medicine and Health, The University of New South Wales, Sydney, NSW 2052, Australia.
Dana WestHospital in the Home Service, Liverpool Hospital, Sydney, Australia.
Sarah TimaHospital in the Home Service, Liverpool Hospital, Sydney, Australia.
Winston ThaiFaculty of Medicine and Health, The University of New South Wales, Sydney, NSW 2052, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsCiprofloxacin has been demonstrated to prolong QT intervals at higher doses beyond those used in conventional practice. We investigated the effect of ciprofloxacin on the QT interval by examining the difference between mean QT intervals (raw and corrected) at baseline and after theoretical achievement of steady state levels in 88 patients receiving oral ciprofloxacin therapy. The utility of a nomogram to decide the cut point for QT interval prolongation was also examined. PATIENTS AND

methodsA retrospective study examined serial surface 12-lead ECGs in a sample of patents prescribed oral ciprofloxacin by physicians in the Department of Ambulatory Care and Hospital in the Home Service at Liverpool Hospital, a tertiary referral hospital in Sydney, Australia. All patients had a baseline ECG and a follow-up ECG after achievement of theoretical steady state.

resultsA total of 88 patients were included. No significant difference in either raw QT or corrected QT using Bazett's formula was observed. Two methods were used to measure the QT interval, one using the median of six observations and one using a single lead. Poor inter-rater reliability for raw measures was observed. A high level of agreement for the cut point for QT prolongation was observed using a nomogram.

conclusionQT and QTc prolongation in a standard 12 lead ECG would not be expected after oral administration of ciprofloxacin at conventional doses. We recommend ECG monitoring to be undertaken only with increased clinical risk.

Indexed as

Anti-Bacterial AgentsCiprofloxacinElectrocardiographyLong QT SyndromeAdministration, OralAdultAgedAged, 80 and overAustraliaFemaleHumansMaleMiddle AgedOutpatientsRetrospective StudiesTertiary Care CentersAnti-Bacterial AgentsCiprofloxacin

Identifiers

PMID41628197
PMCPMC12863266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.