Evidence map›Paper›PMID 41627742›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Metabolomics Analysis of Trypanosomes Using Ion Mobility-Enhanced Mass Spectrometry.

Andrew MacKenzie, Fraser Massie, Tessa Moses

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrew MacKenzieEdinOmics, RRID:SCR_021838, Centre for Engineering Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
Fraser MassieEdinOmics, RRID:SCR_021838, Centre for Engineering Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
Tessa MosesEdinOmics, RRID:SCR_021838, Centre for Engineering Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK. Tessa.Moses@ed.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolomics, the comprehensive study of low-molecular-weight metabolites, provides a direct snapshot of an organism's physiological state and complements genomics and proteomics. Ion mobility (IM) enhanced metabolomics adds crucial gas-phase separation, resolving isobaric and isomeric metabolites for deeper biological insights. Here we describe a method coupling rapid liquid chromatography to IM-enhanced mass spectrometry, which allows high-throughput metabolomics analysis. This method was successfully applied to trypanosomes to elucidate the mode of action of a small-molecule inhibitor in Trypanosoma brucei.

Indexed as

Ion Mobility SpectrometryMass SpectrometryMetabolomeMetabolomicsTrypanosoma brucei bruceiChromatography, LiquidLiquid Chromatography-Mass SpectrometryCollision cross-sectionDrift timeGlobal metabolomicsLiquid chromatographyUntargeted metabolomics

Identifiers

PMID41627742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.