ArticleAnnals of surgical oncology2026
Exploring the Dynamics of Perioperative Quality of Life in Patients with Pancreatic Cancer: A Cross-Lagged Panel Network Analysis.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeOur objective was to assess the perioperative quality of life (QoL) of patients with pancreatic cancer (PC) and accurately capture the complex interactions and causal pointers that contribute to fluctuations.
methodsThis longitudinal study (October 2024 to March 2025) assessed QoL in patients with PC undergoing potentially curative surgery at four stages: the day of admission (T1), 3-5 days postoperatively (T2), the day of discharge (T3), and 1 month postoperatively (T4). Analysis of variance and cross-lagged panel network (CLPN) analyzed stage differences and dynamic interactions, and centrality calculations mapped important intervention targets between stages.
resultsAmong 277 analyzed patients (89.64% response rate from 309 approached), 66.79% had ductal adenocarcinoma; the remaining cases comprised pancreatic neuroendocrine tumors (11.91%), invasive intraductal papillary mucinous neoplasms (7.58%), solid pseudopapillary tumors (5.42%), and other types (8.3%). QoL differed significantly between stages (P < 0.001). Dimension scores for functioning and global health status declined before gradually improving, whereas symptoms followed an inverse pattern. Nodes with higher bridge-expected influence, out-expected influence, or in-expected influence in each CLPN were targets for clinical care (mainly pain and nausea and vomiting in T1→T2, pain and social functioning in T2→T3, and fatigue and financial difficulties in T3→T4). The accuracy and stability of the CLPN were verified as acceptable.
conclusionsThe CLPN could precisely identify the interactions and causal connections among QoL dimensions across different stages. It provides anticipatory and prospective guidance for clinical healthcare professionals to enhance holistic care outcomes through early intervention on vital targets that impede dysfunction and symptom exacerbation.
Indexed as
Identifiers
41627692What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.