Evidence map›Paper›PMID 41627629›Full record

ArticleHepatology international2026

TRIM26 deficiency promotes liver fibrosis progression by mediating macrophage polarization via the EZH2-STAT1 axis.

Wei Zhong, Zile Shao, Tingting Li, Ziyi Xu, Zhixing Gao, Zhizhong Zheng, Yayu Zhang, Houyu Chen, Gang Song

Abstract read
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In one paragraph

Article in Hepatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. E3 Ubiquitin Ligases in MASH-Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei ZhongCancer Research Center, School of Medicine, Xiamen University, Xiamen, 361000, Fujian, China.
Zile ShaoCancer Research Center, School of Medicine, Xiamen University, Xiamen, 361000, Fujian, China.
Tingting LiCancer Research Center, School of Medicine, Xiamen University, Xiamen, 361000, Fujian, China.
Ziyi XuCancer Research Center, School of Medicine, Xiamen University, Xiamen, 361000, Fujian, China.
Zhixing GaoCancer Research Center, School of Medicine, Xiamen University, Xiamen, 361000, Fujian, China.
Zhizhong ZhengCancer Research Center, School of Medicine, Xiamen University, Xiamen, 361000, Fujian, China.
Yayu ZhangCancer Research Center, School of Medicine, Xiamen University, Xiamen, 361000, Fujian, China.
Houyu ChenCancer Research Center, School of Medicine, Xiamen University, Xiamen, 361000, Fujian, China.
Gang SongCancer Research Center, School of Medicine, Xiamen University, Xiamen, 361000, Fujian, China. gangsongsd@xmu.edu.cn.ORCID http://orcid.org/0000-0003-2507-5853

Funding

National Natural Science Foundation of China 82372809Special Funds for the Basic Research and Development Program in the Central Non-profit Research Institutesof China 2023R1001003
6 · The paper itself

Abstract

BACKGROUND AND

aimsLiver fibrosis, a wound-healing response to chronic injury, can progress to cirrhosis and hepatocellular carcinoma. We investigated Tripartite motif-containing protein 26 (TRIM26) in liver fibrosis and its mechanisms.

methodsTRIM26 knockout (Trim26⁻

resultsTRIM26 expression was significantly downregulated in human cirrhotic tissues and fibrotic mouse livers. In Trim26

conclusionTrim26 attenuates liver fibrosis by stabilizing EZH2 and regulating macrophage polarization, which reduces HSC activation.

Indexed as

Enhancer of Zeste Homolog 2 ProteinLiver CirrhosisMacrophagesSTAT1 Transcription FactorUbiquitin-Protein LigasesAnimalsDisease ProgressionHepatic Stellate CellsHumansMacrophage ActivationMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionTripartite Motif ProteinsEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseStat1 protein, mouseSTAT1 Transcription FactorTripartite Motif ProteinsUbiquitin-Protein LigasesEZH2Liver fibrosisMacrophage polarizationSTAT1TRIM26

Identifiers

PMID41627629

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.