Evidence map›Paper›PMID 41627616›Full record

ArticleMolecular biology reports2026

Dapagliflozin attenuates hypothyroidism induced liver and lung dysfunction via regulation of mitophagy and apoptosis.

Marwa Abdeltawab Mohammed, Esraa Mohamed Ali, Manar Fouad Ahmed, Sarah A Eweda, Maha Tarek Mohammed, Dina Sayed Abdelrahim

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Marwa Abdeltawab MohammedDepartment of Medical Physiology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. marwadawaa1@gmail.com.
Esraa Mohamed AliDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Manar Fouad AhmedDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Sarah A EwedaDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Maha Tarek MohammedDepartment of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Dina Sayed AbdelrahimDepartment of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThyroid hormones are mainly concerning with regulation of organs metabolism. Hypothyroidism is a pathological condition characterized by decrease of T3 and T4 level that negatively impact various organs especially liver and lung. Dapagliflozin (DAPA) is an anti diabetic drug posses antioxidant and anti apoptotic properties AIM OF THE STUDY: The aim of this work is to identify the effect of DAPA on disturbance of liver and lung functions result from hypothyroidism MATERIALS AND

methodsTwenty four rats (6 rats/group) were divided into four groups: control group, DAPA group that received DAPA (1 mg/kg/day for five weeks), PTU group that received propylthiouracil (15 mg/kg/day for five weeks), PTU+ DAPA group that received PTU and DAPA as described in the other groups

resultsHypothyroidism induced oxidative stress associated mitophagy disturbance in both lung and liver with development of apoptosis in liver. DAPA avoided this effect

conclusionDAPA protects against liver and lung injury result from hypothyroidism.

Indexed as

Benzhydryl CompoundsGlucosidesHypothyroidismMitophagyAnimalsAntioxidantsApoptosisLiverLungMaleOxidative StressPropylthiouracilRatsRats, WistarAntioxidantsBenzhydryl CompoundsdapagliflozinGlucosidesPropylthiouracilApoptosisDapagliflozinHypothyroidismMitophagyOxidative stress

Identifiers

PMID41627616

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.