Evidence map›Paper›PMID 41627586›Full record

ArticleApoptosis : an international journal on programmed cell death2026

SEMA3E promotes beige adipocyte differentiation and thermogenesis via β-catenin signaling in mice.

Chenxi Xiao, Zhenghua Su, Jialin Zhao, Yajie Hu, Mengting He, Shenhan Xu, Ruoxue Chen, Jie Xu, Jun Chang, Chengshou Lin and 2 more

Abstract read
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In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chenxi Xiao *Department of Orthopaedics, Mindong Hospital Affiliated of Fujian Medical University, No. 89 Heshan Road, Fu'an City, 355000, Fujian, China.
Zhenghua Su *The School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Jialin Zhao *Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Yajie HuPharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Mengting HePharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Shenhan XuPharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Ruoxue ChenPharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Jie XuPharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Jun ChangDepartment of Orthopaedics, Mindong Hospital Affiliated of Fujian Medical University, No. 89 Heshan Road, Fu'an City, 355000, Fujian, China. jchang@fudan.edu.cn.
Chengshou LinDepartment of Orthopaedics, Mindong Hospital Affiliated of Fujian Medical University, No. 89 Heshan Road, Fu'an City, 355000, Fujian, China. lcsmindong@fjmu.edu.cn.
Xinhua LiuDepartment of Orthopaedics, Mindong Hospital Affiliated of Fujian Medical University, No. 89 Heshan Road, Fu'an City, 355000, Fujian, China. liuxinhua@fudan.edu.cn.ORCID 0000-0002-9972-8215
Wugui ChenDepartment of Orthopaedics, Mindong Hospital Affiliated of Fujian Medical University, No. 89 Heshan Road, Fu'an City, 355000, Fujian, China. cwg@fjmu.edu.cn.

Funding

Fujian Provincial Natural Science Foundation Grant No. 2021J011452 and 2022J011513
6 · The paper itself

Abstract

Beige adipocytes play a key role in non-shivering thermogenesis. SEMA3E, a member of the class 3 semaphorin family, is involved in various pathological processes, but its role in adipocyte differentiation and thermogenesis remains unclear. Here, we found SEMA3E expression increased in inguinal white adipose tissue (iWAT) following cold exposure or β-adrenergic agonist CL316,243 stimulation. In vitro, loss- and gain-of-function experiments revealed that SEMA3E promoted beige adipocyte differentiation and enhanced thermogenic genes expression. In vivo, fat transplantation experiments indicated that SEMA3E promoted adipogenesis. Furthermore, adeno-associated virus (AAV)-mediated SEMA3E knockdown in iWAT impaired thermogenesis in mice exposed to cold or CL316,243. RNA-Seq analysis linked SEMA3E to mitochondrial oxidative phosphorylation, and its knockdown reduced mitochondrial respiration by downregulating respiratory chain components expression and lowering mitochondrial oxygen consumption rate. Mechanistically, gene set enrichment analysis suggested SEMA3E regulated beige adipocyte differentiation via the Wnt/β-catenin pathway. SEMA3E knockdown delayed β-catenin degradation, while inhibiting this pathway with IWR-1 rescued the suppressed differentiation and thermogenic genes expression. In conclusion, these findings highlight the crucial role of SEMA3E in beige adipocyte differentiation and thermogenesis.

Indexed as

Adipocytes, Beigebeta CateninCell DifferentiationSemaphorinsThermogenesisAdipogenesisAdipose Tissue, WhiteAnimalsDioxolesMaleMiceMice, Inbred C57BLMitochondriaSignal TransductionWnt Signaling Pathwaybeta CateninDioxolesdisodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylateSemaphorinsBeige adipocyteDifferentiationSEMA3EThermogenesisβ-catenin

Identifiers

PMID41627586

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.