ArticleSleep & breathing = Schlaf & Atmung2026
REM-related obstructive sleep apnoea in neuromuscular diseases: A 10-year retrospective cohort study.
Article in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Establishing polysomnographic criteria for initiation of non-invasive ventilation in children with neuromuscular diseases.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNeuromuscular diseases (NMDs) are reported to have increased obstructive apnoea/hypopnoea during rapid eye movement (REM) sleep; however, the prevalence of REM-related obstructive sleep apnoea (OSA) and its clinical correlates in NMD remain undefined. We evaluated REM sleep, REM-related OSA frequency, and associated with demographic and clinical factors.
methodsWe retrospectively evaluated patients with NMDs who underwent polysomnography (PSG) between 2015 and 2024. Demographic data, morning arterial blood gases, spirometry and PSG data were collected. REM-related OSA required AHI ≥ 5 events/hour, REM-to-non-REM (NREM) AHI ≥ 2, and REM ≥ 30 min; REM-isolated additionally required NREM AHI < 5 events/hour. Patients with OSA who did not meet the criteria for REM-related OSA were classified as having NREM-related OSA.
resultsAmong 290 patients, OSA was present in 87.6% (254/290). REM sleep duration was markedly reduced (11.8 ± 8.0%; 46.8 ± 32.2 min), and 30.0% of patients had REM duration < 30 min. Among OSA with REM ≥ 30 min (n = 182), 54.4% had REM-related OSA; 25.3% were REM-isolated. Compared with NREM-related OSA, the REM-related group exhibited more frequent female sex (p = 0.015), hypertension (p = 0.020), and depression (p = 0.025). In multivariable analysis, REM-related OSA was independently associated with morning hypercapnia (aOR 4.889; 95%CI 1.885-12.680), forced vital capacity (FVC) < 50% and/or ≥ 20% upright-to-supine decline (aOR 3.847; 95%CI 1.085-13.642), and mild OSA (aOR 3.461; 95%CI 1.509-7.937).
conclusionsDespite the marked reduction in REM sleep in NMDs, OSA, and particularly REM-related OSA, is common. In the REM-related OSA group, morning hypercapnia and FVC decline were more frequent. These observations suggest that REM-stage characteristics may be predictive of subsequent chronic respiratory failure.
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