ArticleMikrochimica acta2026
Tailoring of metal organic framework with electrospun polyacrylonitrile for on-chip electromembrane extraction and determination of anticancer drugs in biological samples.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
An on-chip electromembrane extraction integrated with solid-phase microextraction (EME-SPME) was developed for the determination and monitoring of anticancer drugs, including imatinib, irinotecan, and mitomycin C, in various biological fluids. The extraction device incorporated an electrospun polyacrylonitrile (PAN)/MOF-303 nanocomposite fiber, which functioned as the extraction phase. Simultaneous analyte migration under an applied electric field and adsorption onto the nanocomposite surface enabled efficient preconcentration within the compact microfluidic platform. Under optimized conditions, the proposed EME-SPME-HPLC-UV method exhibited low limits of detection ranging from 0.1 to 1.5 µg L
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