Evidence map›Paper›PMID 41627489›Full record

ReviewArchives of microbiology2026

A critical review of natural quorum-sensing inhibitors as molecular anti-virulence agents against phytopathogenic bacteria.

Kayeen Vadakkan, Kavya Santhosh Ponnathodi, Rini Raphael, Meena Kochappan Cheruvathur, Preetha Remadevi, Selvaraj Vijayanand

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kayeen VadakkanAmala Integrated Medical Research Department, Amala Institute of Medical Sciences, Thrissur, 680555, Kerala, India. kayeenvadakkan@gmail.com.
Kavya Santhosh PonnathodiAmala Integrated Medical Research Department, Amala Institute of Medical Sciences, Thrissur, 680555, Kerala, India.
Rini RaphaelDepartment of Zoology, Carmel College (Autonomous), Mala, Thrissur, 680732, Kerala, India.
Meena Kochappan CheruvathurDepartment of Botany, St. Mary's College (Autonomous), Thrissur, 680020, Kerala, India.
Preetha RemadeviCentre for Plant Biotechnology and Molecular Biology, Kerala Agricultural University, Thrissur, 680656, India.
Selvaraj VijayanandBioresource Technology Lab, Department of Biotechnology, Thiruvalluvar University, Vellore, TN, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quorum sensing (QS) is a cell-density-dependent communication process that allows phytopathogenic bacteria to synchronise pathogenicity, mobility, secretion systems, and biofilm development. These signalling networks are pivotal in the progression of plant diseases and serve as promising targets for non-toxic anti-virulence approaches. Prominent quorum-sensing systems in plant-associated bacteria include acyl-homoserine lactone (AHL), diffusible signal factor (DSF), and virulence factor-modifying (VFM) pathways, each regulating distinct pathways involved in pathogenesis. The existing understanding of the molecular structure, signal production, perception, and subsequent control of these quorum-sensing systems in significant phytopathogens, including Pseudomonas syringae, Ralstonia solanacearum, Agrobacterium tumefaciens, Burkholderia glumae, and Dickeya spp., is consolidated. The focus is on quorum-quenching techniques, encompassing enzymatic signal degradation and the influence of natural quorum-sensing inhibitors sourced from plants and microbes, which interrupt communication while preserving bacterial survival. Recent advancements in biochemical characterisation, genomics, and nanotechnology-based delivery technologies are evaluated for their potential to enhance stability and field usability. Collectively, targeting QS-mediated control is a sustainable alternative to traditional agrochemicals, providing exciting opportunities for environmentally friendly approaches to controlling bacterial plant diseases.

Indexed as

Anti-Bacterial AgentsBacteriaPlant DiseasesQuorum SensingAcyl-ButyrolactonesAgrobacterium tumefaciensBacterial ProteinsBurkholderiaDickeyaPlantsPseudomonas syringaeRalstonia solanacearumSignal TransductionVirulenceVirulence FactorsAcyl-ButyrolactonesAnti-Bacterial AgentsBacterial ProteinsVirulence FactorsBiofilm inhibitionPhytopathogenic bacteriaQuorum quenchingQuorum sensing inhibitors

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.