ArticleArchives of microbiology2026
Immunomodulatory effects and gut microbiota modulation by brewer's yeast mannatide in cyclophosphamide-induced immunosuppression mice.
Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Immunomodulation of mixed postbiotics produced from Lactiplantibacillus plantarum KLDS1.0318 and KLDS1.0386 in vitro and in vivo.Archives of microbiology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Yeast is a core microorganism long used in food industry processes such as brewing and baking. This study aimed to investigate the immunomodulatory potential of mannatide (MTE) derived from brewer's yeast in both cyclophosphamide (CTX)-induced immunosuppressed and untreated mice. Results showed that MTE administration alleviated body weight loss, restored organ morphology, and increased immune cytokines (TNF-α and IFN-γ) in immunosuppressed mice. In addition, MTE up-regulated tight junction proteins (Occludin, E-cadherin , and ZO-1) and resolved gut microbial dysbiosis by enriching beneficial bacteria. In untreated mice, MTE significantly increased beneficial bacteria without adverse effects. These findings suggest that MTE exerts immunoenhancing effects in both immunosuppressed and untreated mice by modulating immune parameters and gut microbiota. In conclusion, MTE represents a dietary supplement with immunomodulatory and prebiotic potential, providing a theoretical basis for its application in human health and nutrition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.