Evidence map›Paper›PMID 41627425›Full record

ArticleArchives of microbiology2026

Genomic insights into the genetic diversity, resistance determinants, and plasmid content of carbapenem-resistant Acinetobacter baumannii clinical isolates.

Sezin Unlu Celebi, Suleyman Yalcin, Ozlem Kurt Azap, Aylin Uskudar Guclu

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antimicrobial Resistance and Virulence ofAntibiotics (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sezin Unlu CelebiFaculty of Medicine, Department of Medical Microbiology, Baskent University, Ankara, Türkiye.ORCID http://orcid.org/0000-0001-7490-7981
Suleyman YalcinMicrobiology References Laboratory, Ministry of Health General Directorate of Public Health, Ankara, Türkiye.ORCID https://orcid.org/0000-0003-1434-2717
Ozlem Kurt AzapFaculty of Medicine, Department of Infectious Diseases & Clinical Microbiology, Baskent University, Ankara, Türkiye.ORCID http://orcid.org/0000-0002-3171-8926
Aylin Uskudar GucluFaculty of Medicine, Department of Medical Microbiology, Baskent University, Ankara, Türkiye. auguclu@baskent.edu.tr.ORCID http://orcid.org/0000-0002-1872-028X

Funding

Baskent Üniversitesi DA24/22
6 · The paper itself

Abstract

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a critical nosocomial pathogen with limited therapeutic options. This study aimed to describe clonal relationships among CRAB isolates and genomic insights from representative clusters. A total of 128 non-duplicate CRAB isolates were included in the study. Pulsed-field gel electrophoresis (PFGE) was used to assess clonal relationships and as a preliminary clustering tool for isolate selection. Twelve representative isolates from distinct PFGE clusters were selected for whole-genome sequencing using Oxford Nanopore. Genome assembly, annotation, and comparative analyses were performed using Flye, Prokka, and Roary, respectively. Antimicrobial resistance (AMR) genes, plasmids, insertion sequences, integrons and prophages were identified using the CARD, MOB-suite, ISEscan, IntegronFinder, and PHASTEST tools, respectively. Multilocus sequence typing (MLST) and pangenome analyses were conducted to determine genetic diversity and relatedness among the CRAB isolates. Antibiotic susceptibility testing revealed an extensively drug-resistant phenotype, colistin resistance rate was 23.4%. Mutations in lpxC, lpxD, pmrB, and lpxA were identified in colistin-resistant isolates, suggesting a possible role. Most isolates belonged to the globally disseminated clone ST2

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial AgentsCarbapenemsDrug Resistance, Multiple, BacterialGenetic VariationPlasmidsBacterial ProteinsDrug Resistance, BacterialElectrophoresis, Gel, Pulsed-FieldGenome, BacterialHumansMicrobial Sensitivity TestsMultilocus Sequence TypingAnti-Bacterial AgentsBacterial ProteinsCarbapenemsAntimicrobial resistance geneCarbapenem-resistant Acinetobacter baumanniiCefiderocol resistanceColistin resistanceMobile genetic elements

Identifiers

PMID41627425

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.