Evidence map›Paper›PMID 41627394›Full record

Trial reportStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2026

Long-term cosmetic outcome after intraoperative radiotherapy boost with low-energy X-rays in breast-conserving therapy: a pooled cohort analysis of the TARGIT-BQR and ROKSM trials.

Paulina Schimmelfennig, Christiane Reuter, Uta Kraus-Tiefenbacher, Viktoria Brück, Christina Kaiser, Ralf Keymer, Yasser Abo-Madyan, Katharina Fleckenstein, Benjamin Tuschy, Marc Sütterlin and 6 more

2 registry-linked trialsAbstract readClinical Trial, Phase IVObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01440010 completednot on this map

TARGeted Intraoperative radioTherapy With the INTRABEAM-System as an Advanced Boost in Patients With Breast Cancer - A Quality Control Registry in Germany (TARGIT BQR)

TypeobservationalSponsorUniversitätsmedizin MannheimRan2011 to 2020Enrolled1,133ConditionsBreast CancerArmsIORT with 20 Gy
NCT02114086 unknown statusnot on this map

Prospective Observational Study for Intraoperative Radiotherapy (IORT) of the Breast as a Boost

TypeobservationalSponsorKantonsspital MünsterlingenRan2013 to 2025Enrolled163ConditionsAdverse Effect of Radiation Therapy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Paulina SchimmelfennigDepartment of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Christiane ReuterDepartment of Radiation Oncology, Kantonsspital Münsterlingen, Münsterlingen, Switzerland.
Uta Kraus-TiefenbacherDepartment of Radiation Oncology, Krankenhaus Nordwest, Frankfurt am Main, Germany.
Viktoria BrückAsklepios Klinik Lich GmbH, Lich, Germany.
Christina KaiserUniversity Medical Center Bonn, Medical Faculty Bonn, Bonn University, Bonn, Germany.
Ralf KeymerKlinikum Kassel, Kassel, Germany.
Yasser Abo-MadyanDepartment of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Katharina FleckensteinDepartment of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Benjamin TuschyDepartment of Gynecology and Obstetrics, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Marc SütterlinDepartment of Gynecology and Obstetrics, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Frederik WenzMedical Faculty, University of Freiburg, University Hospital Freiburg, Freiburg, Germany.
Hans ReichardtDepartment of Radiation Oncology, Kantonsspital Münsterlingen, Münsterlingen, Switzerland.
Mathias FehrDepartment of Gynecology and Obstetrics, Kantonsspital Frauenfeld, Frauenfeld, Switzerland.
Markus KutherDepartment of Gynecology and Obstetrics, Kantonsspital Münsterlingen, Münsterlingen, Switzerland.
Sylvia BüttnerDepartment of Medical Biometry, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.
Elena SperkDepartment of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. elena.sperk@medma.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-8771-8124

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study investigates objective long-term cosmetic outcomes in patients with breast cancer after intraoperative radiotherapy applied as a boost (IORT boost) from a pooled international cohort.

methodsA pooled analysis of two prospective studies with IORT boost (low-energy X‑rays, 20 Gy; inclusion criteria: 3.5 cm maximum tumor size and preoperative indication for a boost according to local criteria) during breast-conserving surgery followed by whole-breast radiotherapy (46-50 Gy). The analysis included photos from a subgroup of the prospective phase IV TARGeted Intraoperative radioTherapy (TARGIT) Boost Quality Registry (BQR) study (NCT01440010) with a follow-up of up to 10 years as well as patients from a Swiss study (ROKSM; Spital Thurgau AG; NCT02114086) with a follow-up of 5 years. The pooled analysis included photos from both trials taken at the same timepoints (6 weeks, 6 months, 1 year, 2 years, and 5 years after completion of whole-breast radiotherapy). Cosmetic results were evaluated with the validated BCCT.core software (BCCT.core 2.0, INESC Porto, Portugal) to assess symmetry, color, and scars. A generalized estimating equation (GEE) regression model was used to compare the two cohorts over time.

resultsThe pooled analysis included 777 cosmetic assessments from 276 patients. Across all follow-ups in the pooled analysis, the majority of cosmetic results were rated as excellent or good (61.9%). Patients from TARGIT-BQR had significantly more excellent or good ratings than patients from ROKSM (p < 0.0001). The proportion of patients receiving "excellent" and "good" ratings remained higher in TARGIT-BQR than in ROKSM at every timepoint during follow-up. Overall, for up to 10 years, the majority of ratings in the whole cohort were "excellent" or "good."

conclusionIn this international pooled analysis, the cosmetic outcome after IORT boost followed by whole-breast irradiation shows a good esthetic long-term outcome. Further studies should explore factors that influence cosmetic outcomes and consider additional treatment-related parameters.

Indexed as

Breast NeoplasmsMastectomy, SegmentalAdultAgedCohort StudiesCombined Modality TherapyEstheticsFemaleFollow-Up StudiesHumansMiddle AgedProspective StudiesRadiotherapy, AdjuvantTreatment OutcomeBoostBreast cancerComesisCosmetic outcomeIORT

Identifiers

PMID41627394
PMCPMC13290794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.