Evidence map›Paper›PMID 41627391›Full record

Trial reportSleep2026

Efficacy of pink noise and earplugs for mitigating the effects of intermittent environmental noise exposure on sleep.

Mathias Basner, Michael G Smith, Makayla Cordoza, Matthew S Kayser, Michele Carlin, Adrian J Ecker, Yoni Gilad, Sierra Park-Chavar, Ka'alana Rennie, Victoria Schneller and 6 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05774977 (Study on the Use of Broadband Sound to Mitigate Sleep Disruption Due to Aircraft Noise), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05774977 nacompletednot on this map

Study on the Use of Broadband Sound to Mitigate Sleep Disruption Due to Aircraft Noise

TypeinterventionalSponsorUniversity of PennsylvaniaRan2023 to 2024Enrolled27ConditionsNoise ExposureArmsAviation Noise Only (AN), Pink noise only, 50 dBA (BN50), Aviation Noise With Earplugs (AN+EP), Aviation Noise With Pink Noise, 40 dBA (AN+BN40), Aviation Noise With Pink Noise, 50 dBA (AN+BN50)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mathias BasnerDepartment of Psychiatry, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104, United States.ORCID 0000-0002-8453-0812
Michael G SmithSchool of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 453, 40530 Gothenburg, Sweden.
Makayla CordozaSchool of Nursing, Vanderbilt University, 461 21st Avenue South, Nashville, TN 37240, United States.ORCID 0000-0001-5727-2718
Matthew S KayserDepartment of Psychiatry, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104, United States.
Michele CarlinDepartment of Psychiatry, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104, United States.
Adrian J EckerDepartment of Psychiatry, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104, United States.
Yoni GiladDepartment of Psychiatry, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104, United States.
Sierra Park-ChavarDepartment of Psychiatry, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104, United States.
Ka'alana RennieDepartment of Psychiatry, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104, United States.
Victoria SchnellerDepartment of Psychiatry, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104, United States.
Sinead WalshDepartment of Psychiatry, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104, United States.
Haochang ShouDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104-4310, United States.
Quy CaoDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104-4310, United States.
Magdy YounesSleep Disorders Centre, University of Manitoba, 99 Cornish Avenue, Winnipeg MB R3C 1A2, Canada.
Daniel AeschbachInstitute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, 51147 Cologne, Germany.ORCID 0000-0002-6054-5753
Christopher W JonesDepartment of Psychiatry, Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, 3600 Civic Center Blvd, Philadelphia, PA 19104, United States.ORCID 0000-0002-8173-721X

Funding

FAA Center of Excellence for Alternative Jet Fuels and the Environment 13-C-AJFE-UPENNU.S. Federal Aviation Administration Office of Environment and Energy through ASCENT
6 · The paper itself

Abstract

STUDY

objectivesNighttime environmental noise (EN) exposure disturbs sleep and increases morbidity and mortality. Affordable and effective countermeasures are needed, but rigorous research is scarce. This study investigates the efficacy of pink noise (PN) and earplugs for mitigating the effects of intermittent EN on sleep.

methodsTwenty-five healthy adults (mean ± SD age 28.5 ± 5.9 years, seven male) participated in a seven-night polysomnographic laboratory study with different noise conditions including exposure to EN (93 events; maximum sound pressure level 45 to 65 dBA), PN (40 or 50 dBA), earplugs, and their combination. In the morning, participants completed cognitive tests, cardiovascular measurements, hearing tests, and surveys.

resultsCompared to a noise-free control night, EN reduced N3 deep sleep (p < .0001) while PN reduced REM sleep (p < .001). Adding PN to EN worsened sleep structure, despite minor dose-dependent improvements of EN-induced sleep fragmentation and N3 sleep increases. Earplugs mitigated nearly all EN effects on sleep but started failing at the highest EN level (65 dBA). Morning cognition, cardiovascular measures, and hearing were not affected by nighttime noise, but subjective assessments of sleep, alertness and mood were significantly worse after EN and PN exposure.

conclusionsIn contrast to PN, earplugs proved efficacious in mitigating the effects of EN on sleep. Considering the importance of REM sleep for memory, emotion regulation, and neurodevelopment, the negative effects of PN on REM sleep caution against the widespread and indiscriminate use of broadband noise (BN). Additional research on optimal BN color/level and long-term use is needed, especially in vulnerable populations. CLINICAL

trial registrationRegistered at clinicaltrials.gov under "Broadband Sound and Sleep"; https://clinicaltrials.gov/study/NCT05774977; registration # NCT05774977.

Indexed as

Ear Protective DevicesEnvironmental ExposureNoiseSleepAdultFemaleHumansMalePolysomnographySleep DeprivationSleep StagesYoung Adultawakeningbroadband noisedeep sleep, slow-wave sleepenvironmental noisenoiseREM sleep

Identifiers

PMID41627391
PMCPMC13163165

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.