ArticleeLife2026
Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B.
Abstract read
In one paragraph
Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Looking back at the TEDDY study: lessons and future directions.Nature reviews. Endocrinology · 2025Review
- Epoxidase inhibitor-aspirin resistance and the relationship with genetic polymorphisms: a review.The Journal of international medical research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Ozkan AydemirUniversity of Massachusetts Chan Medical School, Worcester, United States.ORCID https://orcid.org/0000-0002-3458-6527
Jeffrey A BaileyDepartment of Pathology and Laboratory Medicine and Center for Computational Molecular Biology, Brown University, Providence, United States.ORCID https://orcid.org/0000-0002-6899-8204
Daniel AgardhDepartment of Clinical Sciences, Lund University CRC Skane University Hospital, Malmö, Sweden.ORCID https://orcid.org/0000-0003-1435-1234
Åke LernmarkDepartment of Clinical Sciences, Lund University CRC Skane University Hospital, Malmö, Sweden.ORCID https://orcid.org/0000-0003-1735-0499
Janelle A NobleUniversity of California, San Francisco, San Francisco, United States.ORCID https://orcid.org/0009-0002-5529-1186
Agnes Andersson SvärdDepartment of Clinical Sciences, Lund University CRC Skane University Hospital, Malmö, Sweden.ORCID https://orcid.org/0000-0002-6838-7382
Elizabeth P BlankenhornDrexel University College of Medicine, Philadelphia, United States.ORCID https://orcid.org/0000-0002-6331-0319
Hemang M ParikhHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, United States.ORCID https://orcid.org/0000-0002-9076-6709
Anette-G ZieglerInstitute of Diabetes Research, Helmholtz Zentrum München, Klinikum rechts der Isar, Technische Universität München, and Forschergruppe Diabetes e.V., Neuherberg, Germany.ORCID https://orcid.org/0000-0002-6290-5548
Jorma ToppariResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, and Centre for Population Health Research, University of Turku, Turku, Finland.
Beena AkolkarNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, United States.
William A HagopianPediatrics, Indiana University School of Medicine, Indianapolis, United States.ORCID https://orcid.org/0000-0003-2979-0475
Marian J RewersBarbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, United States.ORCID https://orcid.org/0000-0003-3829-9207
John P MordesUniversity of Massachusetts Chan Medical School, Worcester, United States.ORCID https://orcid.org/0000-0003-2414-380X
TEDDY Study Group
Funding
Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)U01DK128847 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI JEFFREY P KRISCHER · 2021 to 2026
$79.2MData Coordinating Center (DCC)for the Consortium for Identification of EnvironmenUC4DK095300 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2011 to 2011
$56.0MNIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1MData Coordinating CenterU01DK063790 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2002 to 2006
$50.1MFollow-up on Subjects, Integrative Data Analysis and Measurement of Viral Antibodies in The Environmental Determinants of Diabetes in The Young Study (TEDDY)U01DK124166 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2020 to 2022
$31.1MNIDDK Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)UC4DK117483 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2017 to 2020
$30.4MEstablish a Data Coordinating Center (DCC) for the Consortium for Identification UC4DK100238 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2014
$28.9MThe Study of Epigenetics and Infections in The Environmental Determinants of Diabetes in the Young (TEDDY)UC4DK112243 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2016 to 2016
$27.0MData Coordinating Center (DCC) for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY) StudyUC4DK106955 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2015 to 2015
$20.0MThe Environmental Determinants of Diabetes in Young (TEDDY0U01DK063863 · NIDDK · HOSPITAL DISTRICT OF SOUTHWEST FINLAND · PI TOPPARI, JORMA · 2003 to 2022
$13.5MThe Environmental Triggers of Diabetes (TEDDY) in SwedenU01DK063861 · NIDDK · UNIVERSITY OF WASHINGTON · PI LERNMARK, AKE · 2003 to 2022
$13.4MTHE TEDDY STUDY - COLORADO CLINICAL CENTERU01DK063821 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 2003 to 2022
$12.3MNCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR002535NIDDK NIH HHS HHSN267200700014CNIDDK NIH HHS U01 DK063790NIDDK NIH HHS U01 DK063821NIDDK NIH HHS U01 DK063829NIDDK NIH HHS U01 DK063836NIDDK NIH HHS U01 DK063861NIDDK NIH HHS U01 DK063863NIDDK NIH HHS U01 DK063865NIDDK NIH HHS U01 DK124166NIDDK NIH HHS U01 DK128847NIDDK NIH HHS U01 DK63790NIDDK NIH HHS U01 DK63821NIDDK NIH HHS U01 DK63829NIDDK NIH HHS U01 DK63836NIDDK NIH HHS U01 DK63861NIDDK NIH HHS U01 DK63863NIDDK NIH HHS U01 DK63865NIDDK NIH HHS UC4 DK063821NIDDK NIH HHS UC4 DK063829NIDDK NIH HHS UC4 DK063836NIDDK NIH HHS UC4 DK063861NIDDK NIH HHS UC4 DK063863NIDDK NIH HHS UC4 DK063865NIDDK NIH HHS UC4 DK095300NIDDK NIH HHS UC4 DK100238NIDDK NIH HHS UC4 DK106955NIDDK NIH HHS UC4 DK112243NIDDK NIH HHS UC4 DK117483NIDDK NIH HHS UC4 DK63821NIDDK NIH HHS UC4 DK63829NIDDK NIH HHS UC4 DK63836NIDDK NIH HHS UC4 DK63861NIDDK NIH HHS UC4 DK63863NIDDK NIH HHS UC4 DK63865NIDDK NIH HHS UC4 DK95300NLM NIH HHS HHSN267200700014C
Abstract
Polymorphisms in genes in the human leukocyte antigen (HLA) class II region comprise the most important inherited risk factors for many autoimmune diseases, including type 1 diabetes (T1D) and celiac disease (CD): both diseases are positively associated with the HLA-DR3 haplotype (
Indexed as
Celiac DiseaseComplement C4aDiabetes Mellitus, Type 1Genetic Predisposition to DiseaseHLA-DR alpha-ChainsIntronsPolymorphism, Single NucleotideAdolescentAdultChildFemaleHaplotypesHumansMaleYoung AdultComplement C4aHLA-DR alpha-Chainsceliac diseasecomplementdiabetesgeneticsgenomicshumanimmunologyinflammationT1D
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC0
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.