ArticleJournal of the American Chemical Society2026
Seven-Membered Azacyclic Allenes: Synthesis, Trapping, and Stereochemical Transfer Studies.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Diradical Character of Cyclic Allenes Enables Their Thermal (2 + 2) Cycloadditions.Journal of the American Chemical Society · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Methods for the synthesis of functionalized seven-membered rings, especially those containing nitrogen atoms, are underdeveloped but remain coveted. We report the chemistry of seven-membered azacyclic allenes as a means to access ring-fused azepanes that possess up to three newly formed stereocenters. We demonstrate that seven-membered azacyclic allenes outperform their six-membered counterparts in enantiospecific cycloaddition studies, consistent with computational predictions of enantiomerization barriers. Beyond providing a practical method for annulated azepane synthesis and elucidating selectivity trends, our findings offer insight into the interplay between cyclic allene ring size and enantiospecificity in trapping experiments. These studies are expected to further enable the use of strained cyclic allenes in synthesis.
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Registered trials
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