Evidence map›Paper›PMID 41626805›Full record

ReviewBiochemical Society transactions2026

Plasticity and stringency: rethinking stem cell division modes.

Muhammed Burak Bener, Mayu Inaba

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemical Society transactions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Muhammed Burak BenerDepartment of Cell Biology, University of Connecticut School of Medicine, Farmington, CT 06030, U.S.A.ORCID 0000-0002-0215-0788
Mayu InabaDepartment of Cell Biology, University of Connecticut School of Medicine, Farmington, CT 06030, U.S.A.ORCID 0000-0002-8508-7461

Funding

Nanotube-mediated regulation of niche-stem cell signalingR35GM128678 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Mayu Inaba-Oguro · 2018 to 2026
$3.3M
NIGMS NIH HHS R35 GM128678
6 · The paper itself

Abstract

Asymmetric cell division (ACD) has been extensively studied in various stem cell systems as a fundamental mechanism that ensures the balance between stem cell self-renewal and differentiation. ACD allows one daughter cell to retain stem cell identity while the other commits to differentiation, thereby maintaining tissue homeostasis over time. Stem cells also undergo symmetric cell division, in which both daughter cells adopt either stem or differentiated fates. What are the outcomes of each cell division mode, and how strictly are these modes executed across different stem cell systems? There have been technical challenges of visualizing stem cell division in vivo due to the structural complexity of tissues and the rarity and ambiguous identity of genuine stem cells. Despite these difficulties, recent technical advancements have revealed how these cells operate within their native environments. This review summarizes key studies that elucidate distinct division modes and their functional outcomes across various stem cell systems.

Indexed as

Asymmetric Cell DivisionCell DivisionStem CellsAnimalsCell DifferentiationHumansasymmetric cell divisionStem cell clonal expansionStem cell heterogeneitysymmetric cell division

Identifiers

PMID41626805
PMCPMC12905486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.