Evidence map›Paper›PMID 41626627›Full record

ArticleInternational journal of genomics2026

IER3 Promotes Malignant Progression of Colorectal Cancer Through the NF-

Zhigang Wei, Yinyi Luo, Yupeng Zhang, Qingxing Huang, Jianhang Shao, Yingying Zhang, Yuqi Zhang, Zhimin Wang, Chaojie Liang, Zhiyong Lai and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhigang WeiDepartment of Pathology, School of Basic Medical Science, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.
Yinyi LuoThe First Clinical Medical School, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.ORCID https://orcid.org/0000-0003-4093-6324
Yupeng ZhangThe First Clinical Medical School, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.
Qingxing HuangDepartment of Colorectal Surgery, The First Hospital, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.
Jianhang ShaoThe First Clinical Medical School, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.
Yingying ZhangDepartment of Pathology, School of Basic Medical Science, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.ORCID https://orcid.org/0000-0002-2213-5542
Yuqi ZhangThe First Clinical Medical School, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.
Zhimin WangDepartment of Colorectal Surgery, The First Hospital, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.
Chaojie LiangDepartment of Biliary and Pancreatic Surgery, The First Hospital, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.
Zhiyong LaiDepartment of Biliary and Pancreatic Surgery, The First Hospital, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.ORCID https://orcid.org/0000-0002-2631-9680
Yongping CuiDepartment of Pathology, School of Basic Medical Science, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.ORCID https://orcid.org/0000-0001-9731-883X
Pengpeng ZhangDepartment of Pathology, School of Basic Medical Science, Shanxi Medical University, Taiyuan, China, sxmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, primarily due to metastatic progression and an immunosuppressive tumor immune microenvironment (TIME). The stress-responsive gene IER3 is found to be dysregulated in multiple cancers. Currently, its functional role in CRC pathogenesis and immune modulation remains poorly understood. Here, using integrated single-cell RNA sequencing (scRNA-seq) of clinical samples, we identify a distinct IER3-expressing malignant subpopulation associated with aggressive disease and poor prognosis. Functional studies demonstrate that IER3 drives CRC proliferation, invasion, and metastatic capacity both

Indexed as

colorectal cancerimmune checkpoint blockadeimmune escapeimmunosuppressiontumor immune microenvironment

Identifiers

PMID41626627
PMCPMC12859389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.