ArticleFrontiers in systems biology2025
A synthetic biology toolkit for rationally designing genetic circuits in
Article in Frontiers in systems biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Antimicrobial resistance (AMR) poses a severe global health threat, with Methods: To combat AMR through synthetic biology, this study characterizes a library of BioBrick parts to be adopted in Results: Key components were characterized, including two plasmid vectors, a library of inducible and constitutive promoters, and a CRISPRi-mediated repression system; for the latter, a testbed for biofilm-related genes implicated in the downregulation of antibiotic resistance is also provided. Discussion: By enabling tunable transcriptional control through the characterized promoters and ensuring the ability to downregulate gene expression via CRISPRi, this synthetic biology toolkit lays the foundation for the rational design of genetic circuits to study and counteract AMR in
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.