Evidence map›Paper›PMID 41626526›Full record

ArticleEpigenetics reports2026

Chromatin Meets Condensates: Emerging Interplays Linking Nuclear Paraspeckles to Gene Activation.

Chih-Han Tu, Chen-I Hsu, Jia-Ray Yu

Abstract read
In one paragraph

Article in Epigenetics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chih-Han TuDivision of Cellular and Molecular Pathogenesis, Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Chen-I HsuDivision of Cellular and Molecular Pathogenesis, Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Jia-Ray YuDivision of Cellular and Molecular Pathogenesis, Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.

Funding

Regulation of canonical and non-canonical substrates of histone lysine methyltransferasesR35GM160046 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Jia-Ray Yu · 2025 to 2026
$870k
NIGMS NIH HHS R35 GM160046
6 · The paper itself

Abstract

Nuclear paraspeckles are membrane-less protein-protein and protein-RNA condensates that assemble co-transcriptionally upon the expression of long non-coding RNA NEAT1. While efforts in the past two decades extensively characterized the components and structures of nuclear paraspeckles, their biochemical, cellular, and physiological functions remain largely unclear. Emerging evidence has revealed that paraspeckles physically interact with active chromatin and promote its establishment, implicating the role of paraspeckles as a functional hub to maintain the active state of chromatin. Here, we discuss recent advances and key knowledge gaps in the biology of paraspeckles, including their interplay with active chromatin, disease associated mutations, and functional discrepancies between mouse and human systems.

Indexed as

active chromatinhuman developmentnuclear paraspeckles

Identifiers

PMID41626526
PMCPMC12858287

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.