Evidence map›Paper›PMID 41626492›Full record

ArticleACS omega2026

The Role of Spacer Segments in Increasing the Transfection Efficacy of Au-Core Polymeric-Shell Nanoparticulate Gene Vectors.

Denisse I Bostiog, Valentin Nastasa, Cristina M Al-Matarneh, Dragos Peptanariu, Mihai Mares, Sorin A Pasca, Andra C Bostanaru-Iliescu, Bogdan F Craciun, Tudor Vasiliu, Razvan Puf and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Denisse I BostiogCentre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania.
Valentin NastasaLaboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 8 Mihail Sadoveanu Alley, Iasi 700489, Romania.ORCID https://orcid.org/0000-0001-7384-8692
Cristina M Al-MatarnehCentre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania.ORCID https://orcid.org/0000-0001-9299-1347
Dragos PeptanariuCentre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania.
Mihai MaresLaboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 8 Mihail Sadoveanu Alley, Iasi 700489, Romania.
Sorin A PascaLaboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 8 Mihail Sadoveanu Alley, Iasi 700489, Romania.
Andra C Bostanaru-IliescuLaboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 8 Mihail Sadoveanu Alley, Iasi 700489, Romania.
Bogdan F CraciunCentre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania.ORCID https://orcid.org/0000-0002-2324-0088
Tudor VasiliuCentre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania.
Razvan PufCentre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania.
Stelian S MaierCentre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania.
Mariana PintealaCentre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania.ORCID https://orcid.org/0000-0002-4021-982X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The surface chemistry of gold nanoparticles is a key determinant of their final biological properties. In this study, we investigated the influence of the PEG chain length, positioned between the gold core and the cationic polymer, on the transfection efficiency in HeLa and HGF cell lines. Two types of nonviral vectors were synthesized from the same AuNPs, which were subsequently functionalized with PEG of 1000 and 2500 Da, respectively. Onto these PEG chains, identical copolymeric sequences of PEI2000-PEG500-GA were covalently attached to provide quasi-shielding (via PEG500) and enable tumor targeting/accumulation (via GA). Both vectors demonstrated that such functionalization enhances cellular uptake and targeting specificity while exhibiting excellent DNA delivery efficiency, minimal

Identifiers

PMID41626492
PMCPMC12854498

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.