ArticleACS omega2026
Exposing the Airway Surface to the Neonicotinoid Clothianidin Alters the Electrophysiological Properties of Human Airway Epithelia.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neonicotinoid clothianidin is used indoors and outdoors as an insecticide and extensively as a seed coating in agriculture where working solutions are prepared at 4000 ppm. Health effects of clothianidin are often studied under the assumption that ingestion is the exposure route, yet inhalation exposures are likely, given that clothianidin is sprayed and dust is resuspended. We studied the effect of airway exposure to clothianidin using human donor epithelia. Acute clothianidin doses greater than 50 ppm applied to the apical (airway-facing) surface resulted in decreased ion transport properties, specifically, decreased activity of the surface sodium channel, ENaC. During a 6 h 500 ppm clothianidin exposure, the permeability of airway epithelia to clothianidin rose from ∼4.2 × 10
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Registered trials
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