Evidence map›Paper›PMID 41626399›Full record

ArticleBone reports2026

Development of a large porcine model of osteogenesis imperfecta type I.

Maria E Aguirre-Flores, Leah E Tokach, Eric Cheang, Gregory Trahan, Dennis A Webster, Adrienne L Watson, Daniel F Carlson, David R Deyle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria E Aguirre-FloresDepartment of Clinical Genomics, Mayo Clinic, 200 First St. SW Rochester, MN, 55905, Mayo Building, 19E, United States of America.
Leah E TokachDepartment of Clinical Genomics, Mayo Clinic, 200 First St. SW Rochester, MN, 55905, Mayo Building, 19E, United States of America.
Eric CheangDepartment of Molecular Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, United States of America.
Gregory TrahanDepartment of Clinical Genomics, Mayo Clinic, 200 First St. SW Rochester, MN, 55905, Mayo Building, 19E, United States of America.
Dennis A WebsterRecombinetics, 3388 Mike Collins Drive, Eagan, MN, 55121, United States of America.
Adrienne L WatsonWorld Precision Instruments LLC, Bradenton, FL, United States of America.
Daniel F CarlsonRecombinetics, 3388 Mike Collins Drive, Eagan, MN, 55121, United States of America.
David R DeyleDepartment of Clinical Genomics, Mayo Clinic, 200 First St. SW Rochester, MN, 55905, Mayo Building, 19E, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteogenesis imperfecta (OI) comprises a group of disorders that lead to bone fragility. The most common forms are caused by pathogenic variants in COL1A1 and COL1A2. There are many different animal models OI from zebrafish to dogs, with murine models being the most used model. In this brief study, we describe the successful generation of the first large animal porcine model of OI Type I carrying a clinically relevant pathogenic variant, c.757C>T (p.Arg253Ter). These pigs exhibited classic features of OI Type I including blue sclera, low bone mass, and bone fragility. This model is more genetically and physiologically similar to humans and will be useful in studying the skeletal and extra-skeletal symptoms associated with OI.

Indexed as

BoneOsteogenesis imperfectaPig model

Identifiers

PMID41626399
PMCPMC12860256

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.