ArticleFrontiers in public health2025
Association between BMI and knee osteoarthritis in Chinese adults aged 45 years and older: evidence from the 2021 Global Burden of Disease analysis and the China Health and Retirement Longitudinal Study.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Amidst the dual challenges of rapid population aging and rising obesity prevalence, knee osteoarthritis (KOA) constitutes a major public health burden in China. This study examined the association between body mass index (BMI) and KOA in Chinese adults, and aimed to identify clinically meaningful BMI thresholds for weight management interventions. Methods: Using data from the Global Burden of Disease 2021 Study (1990-2021), we quantified the KOA burden attributable to high BMI and assessed age-specific temporal trends. We further analyzed data from the China Health and Retirement Longitudinal Study (CHARLS), including participants aged ≥45 years after excluding those with missing BMI, KOA, or covariate information and those with BMI values outside 15-40 kg/m Results: In 2021, China recorded 1.11 million disability-adjusted life years (DALYs) attributable to high BMI among individuals with KOA, a 369.28% increase from 1990. After age standardization, the DALYs rate increased by 91.68%, with an average annual increase of 2.13% ( Conclusion: A BMI of 26.89 kg/m
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