Evidence map›Paper›PMID 41626295›Full record

ArticleCell insight2026

An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.

Fang-Xu Li, Sheng Liu, Zhi-Dong Zhang, Xin Shuai, Bi-Kun Xiao, Jia Yang, Defen Lu, Dandan Lin, Guijun Shang, Bo Zhong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fang-Xu LiDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Cancer Center, Renmin Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, College of Life Sciences, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Sheng LiuInstitute of Pediatrics, Shenzhen Children's Hospital, Shenzhen 518038, China.
Zhi-Dong ZhangDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Cancer Center, Renmin Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, College of Life Sciences, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Xin ShuaiDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Cancer Center, Renmin Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, College of Life Sciences, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Bi-Kun XiaoDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Cancer Center, Renmin Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, College of Life Sciences, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Jia YangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, Shanxi, China.
Defen LuCollege of Life Sciences, Shanxi Agricultural University, Taiyuan 030031, Shanxi, China.
Dandan LinDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Cancer Center, Renmin Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, College of Life Sciences, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Guijun ShangThe Key Laboratory of Medical Molecular Cell Biology of Shanxi Province, Institutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, Shanxi, China.
Bo ZhongDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Cancer Center, Renmin Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, College of Life Sciences, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, Wuhan University, Wuhan 430071, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STING-associated vasculopathy with onset in infancy (SAVI) is an autoimmune disease caused by gain-of-function mutations (GOFs) of MITA/STING and the most frequent GOFs for SAVI are MITA

Indexed as

ER-To-Golgi translocationMITA gain-of-function mutationsMITA/STINGSAVISAVI-Inhibitory peptideTherapeutic intervention

Identifiers

PMID41626295
PMCPMC12857359

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.