ArticleAlzheimer's & dementia (New York, N. Y.)
Cognitive training, alone and combined with acetylcholinesterase inhibitors, in neurocognitive disorders: long-term efficacy and the role of cognitive reserve on 30 months of intervention.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Cognitive training, alone and combined with acetylcholinesterase inhibitors, in neurocognitive disorders: long-term efficacy and the role of cognitive reserve on 30 months of intervention.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionNon-pharmacological interventions are increasingly relevant in neurocognitive disorders (NCDs) management. Cognitive training (CT) may benefit early stages, when functional resources allow targeted stimulation. However, its long-term effects and interaction with acetylcholinesterase inhibitors (AChEI) remain underexplored. This study aimed to investigate the 30-month efficacy of CT, alone or combined with AChEI, in older adults with mild NCD, considering the moderating role of cognitive reserve (CR) and individual characteristics.
methodsA total of 108 individuals (mean age = 75.1 ± 6.5; 56.5% females) received either repeated CT alone (
resultsCT-only individuals showed greater and more consistent cognitive improvements over time compared to the CT+AChEI group (MMSE: DISCUSSION: Sustained CT supports cognition in NCDs, particularly for those with lower CR. The combination with AChEI did not provide additional benefit and may reduce long-term effectiveness, warranting further investigation. Findings emphasize the importance of tailored, long-term approaches accounting for individual profiles. Highlights: Cognitive training improved cognition over 30 months in mild NCDs.CT alone outperformed combined CT+AChEI treatment in long-term cognitive outcomes.Individuals with lower CR benefited most from CT.Males showed greater cognitive gains, particularly in the CT-only group.Long-term CT efficacy supports real-world applicability in early NCD care.
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