Evidence map›Paper›PMID 41626276›Full record

ArticleGeoHealth2026

A Regionally Determined Climate-Informed West Nile Virus Forecast Technique.

Ryan D Harp, Karen M Holcomb, Stanley G Benjamin, Benjamin W Green, Hunter Jones, Michael A Johansson

Abstract read
In one paragraph

Article in GeoHealth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryan D HarpGlobal Systems Laboratory National Oceanic and Atmospheric Administration Boulder CO USA.ORCID https://orcid.org/0000-0002-2872-8541
Karen M HolcombDivision of Vector-Borne Diseases Centers for Disease Control and Prevention Fort Collins CO USA.ORCID https://orcid.org/0000-0002-9403-3756
Stanley G BenjaminGlobal Systems Laboratory National Oceanic and Atmospheric Administration Boulder CO USA.ORCID https://orcid.org/0000-0002-5751-8236
Benjamin W GreenGlobal Systems Laboratory National Oceanic and Atmospheric Administration Boulder CO USA.ORCID https://orcid.org/0000-0002-9483-094X
Hunter JonesClimate Program Office National Oceanic and Atmospheric Administration Silver Spring MD USA.ORCID https://orcid.org/0000-0003-4588-3911
Michael A JohanssonDivision of Vector-Borne Diseases Centers for Disease Control and Prevention San Juan PR USA.ORCID https://orcid.org/0000-0002-5090-7722

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

West Nile virus (WNV) infection has caused over 30,000 human cases of the severe, neuroinvasive form of the disease (West Nile virus Neuroinvasive Disease; WNND) and nearly 3,000 deaths in the U.S. Despite known links to observable climate factors, no effective nationwide WNV or WNND forecast exists. We aimed to produce a skillful, nationwide WNND forecast built upon regionally varying relationships between climate factors and WNND. After examining the relationships between climate conditions and annual WNND caseload for 11 regions in the U.S., we incorporated the most salient climate factors-most commonly drought and temperature-into a regionally determined nationwide WNND statistical forecast model using a Bayesian regression framework. We retrospectively generated forecasts from 2005 to 2022 and compared forecast skill against various benchmarks, including a simple, historical case-driven model. Our regional, climate-informed WNND retrospective forecasts outperformed a benchmark model only informed by historical WNND case data across all regions, as well as in a nationally aggregated score (univariable: 18.8% [4.7%-27.7%], bivariable: 21.8% [7.0%-30.7%] improvement). The regional forecasts also outperformed an ensemble model generated from a recent WNV forecasting competition and a parallel, county-level, regional climate-informed forecast outperformed forecasts from the same competition. Importantly, our approach to WNND forecast development aggregated county-level data to broader regions to boost statistical signal and capture the regionally varying influences of climate conditions on annual WNND caseload. The advances here represent a potential path toward actionable broad-scale WNV forecasts.

Indexed as

Bayesian regressiondisease forecastingNEONregionalvector‐borne diseasewest nile virus neuroinvasive disease

Identifiers

PMID41626276
PMCPMC12856058

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.