ArticleFrontiers in medicine2026
Sedation level variability an indicator for mortality in mechanical ventilated critically ill patients: a propensity score-weighted cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Predicting Adverse ICU Outcomes from Admission-Time Frailty and Nocturnal Sleep Fragmentation Using Explainable AI.Journal of clinical medicine · 2026Article
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5 authors.
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Abstract
Objective: To investigate the impact of low versus high sedation level variability (SLV), measured during the first 72-h intensive care unit (ICU) stay, on clinical outcomes in ventilated critically ill patients. Methods: Patients were identified from the Medical Information Mart for Intensive Care IV database from 2008 to 2019. The SLV was quantified by calculating the coefficient of variation (CV) using 18 time-series exponentially transformed Richmond Agitation-Sedation Scale (RASS) scores for each patient. Based on the median of the CV, patients were divided into the low and high SLV groups, which were subsequently balanced by a stabilized inverse probability of treatment weighting method. Results: Compared to the high SLV group ( Conclusion: A reduced SLV, measured during the first 72-h ICU stay, is associated with an increased risk of both 28-day and 90-day ICU mortality in ventilated critically ill patients. Patients with < 60% of RASS scores within the target range are especially vulnerable to this negative impact.
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