Evidence map›Paper›PMID 41626220›Full record

ArticleResuscitation plus2026

Tonicity and colloid osmotic pressure drive microvascular recovery from low volume hypotensive resuscitation from hemorrhagic shock.

Carlos Munoz, Daniela Lucas, Krianthan Govender, Jacinda Martinez, Cynthia Muller, Zhixuan Song, Destiny Okechukwu-Nwabueze, Pedro Cabrales

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carlos MunozDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, United States.
Daniela LucasDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, United States.
Krianthan GovenderDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, United States.
Jacinda MartinezDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, United States.
Cynthia MullerDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, United States.
Zhixuan SongDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, United States.
Destiny Okechukwu-NwabuezeDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, United States.
Pedro CabralesDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, United States.

Funding

Bioengineering a Dual Function Protein Construct to Detoxify Heme and HemoglobinR01HL159862 · NHLBI · OHIO STATE UNIVERSITY · PI BUEHLER, PAUL WERNER, CABRALES, PEDRO · 2021 to 2024
$2.6M
Training in Bioengineering Research and Technology Development in Cardiovascular in Cardiopulmonary Health and DiseaseT32HL160507 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Karen L Christman, Andrew D. McCulloch · 2022 to 2026
$1.6M
NHLBI NIH HHS R01 HL159862NHLBI NIH HHS T32 HL160507
6 · The paper itself

Abstract

Hypertonic saline solution containing 7.5% sodium chloride provides rapid intravascular volume expansion during severe hypovolemic shock, reducing the total fluid required to restore perfusion. Unlike traditional large-volume crystalloid resuscitation, which dilutes circulating blood components, hypertonic saline mobilizes intracellular and interstitial fluids into the vascular space, improving perfusion with minimal infusion volume. This strategy is particularly valuable in military and emergency settings where rapid stabilization and limited fluid availability are critical. In this study, we integrated ex vivo rheological analyses and in vivo microvascular measurements to elucidate the mechanisms underlying low-volume resuscitation with hypertonic saline. In a rheological perspective, using controlled shear flow conditions ranging from 1 to 1,000 s

Indexed as

Colloid osmotic pressureHemorrhagic shockHypertonic salineLow-volume resuscitationMicrocirculationMicrovascular perfusion

Identifiers

PMID41626220
PMCPMC12859221

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.