Evidence map›Paper›PMID 41626179›Full record

ArticleFrontiers in oncology2025

Association of thyroid disease and intracranial meningiomas: a retrospective analysis with external validation.

Jonathan B Bell, Max A Saint-Germain, Carlen A Yuen, Andrew Wilmington, Laura Dresser, Matthew T Walker, Christopher R Trevino, Roberto Salvatori, Debraj Mukherjee, David O Kamson and 1 more

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Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Jonathan B BellPreliminary Internal Medicine Program, University of Chicago (Endeavor), Evanston, IL, United States.
Max A Saint-GermainSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, United States.
Carlen A YuenDepartment of Neurology, University of Chicago, Chicago, IL, United States.
Andrew WilmingtonDivision of Hematology, Oncology, and Cell Therapy, Rush University Medical Center, Chicago, IL, United States.
Laura DresserDepartment of Neurology, University of Chicago, Chicago, IL, United States.
Matthew T WalkerDepartment of Radiology, Endeavor Health, Evanston, IL, United States.
Christopher R TrevinoDepartment of Neurology, Endeavor Health, Evanston, IL, United States.
Roberto SalvatoriDivision of Endocrinology and Pituitary Center, Johns Hopkins University, School of Medicine, Baltimore, MD, United States.
Debraj MukherjeeJohns Hopkins University, Department of Neurosurgery, Baltimore, MD, United States.
David O KamsonSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, United States.
Ryan MerrellDepartment of Neurology, Vanderbilt University, Nashville, TN, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The scope of comorbid conditions with meningiomas is understudied. There is limited published evidence to date suggesting higher prevalence of thyroid diseases in patients with meningiomas. This retrospective study was designed to evaluate this association. Methods: The medical records from 584 patients with intracranial meningiomas were reviewed. The prevalence of thyroid disease was calculated as well as odds ratios to compare patient cohorts. Subsequently, the results were externally validated using SlicerDicer data from a second institution's electronic medical record. Results: Within the Endeavor Intracranial Meningioma cohort, thyroid disease was found in 196/584 (33.6%): hypothyroidism in 154/584 (26.4%), nodular disease in 34/584 (5.8%), thyroid cancer in 9/584 (1.5%), and hyperthyroidism in 8/584 (1.4%) patients. An additional 9/584 (1.5%) patients had a different thyroid disease or diagnosis. Our external validation with patients only from the second institution yielded significant association of meningioma with thyroid hormone medication use (OR = 6.1), hypothyroidism (OR = 7.5), thyroid cancer (OR = 14.6), hyperthyroidism (OR = 5.9), and thyroid nodules (OR = 10.8). Comparing meningioma patients to patients with glioblastoma yielded a similar association between meningioma and general thyroid disorders (OR = 2.1), thyroid hormone usage (OR = 2.1), hypothyroidism (OR = 1.7), thyroid cancer (OR = 3.1), and thyroid nodules (OR = 7.5). These observations were not confounded by female overrepresentation. Conclusions: This study confirms thyroid disease, particularly hypothyroidism, to be a common comorbid condition in patients with intracranial meningiomas in two independent datasets. Further research is needed to assess the role of thyroid disorders in the outcomes for patients with meningioma.

Indexed as

hypothyroidismmeningiomaneuro-oncologythyroid disordersthyroid hormone replacementthyroid nodular disease

Identifiers

PMID41626179
PMCPMC12851958

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