ArticleGynecologic oncology reports2025
Erythropoietin-Secreting uterine leiomyoma presenting with secondary erythrocytosis: A case report.
Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Polycythemia is a rare paraneoplastic phenomenon associated with benign and malignant tumors, including uterine leiomyomas. Few cases of secondary erythrocytosis due to erythropoietin (EPO)-producing fibroids have been reported. Tumor resection is the mainstay of treatment for paraneoplastic polycythemia. Case: We describe a 44-year-old woman who presented with a large uterine mass and elevated hemoglobin and hematocrit. Evaluation included elevated serum EPO level. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and lymphadenectomy for bulky adenopathy. Final histopathology confirmed a benign leiomyoma. Following surgery, HGB level normalized. Conclusion: Although uncommon, EPO-secreting uterine fibroids should be considered in the differential for erythrocytosis, particularly when other causes are not evident.
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