Evidence map›Paper›PMID 41626062›Full record

ArticleGastroenterology & hepatology2025

Primary Biliary Cholangitis: Novel and Emerging Therapies.

Keri-Ann Buchanan-Peart, Divya Dasani, Cynthia Levy

Abstract read
In one paragraph

Article in Gastroenterology & hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Keri-Ann Buchanan-PeartDivision of Digestive Health and Liver Diseases, University of Miami Miller School of Medicine, Miami, Florida.
Divya DasaniDepartment of Internal Medicine, Jackson Memorial Hospital/University of Miami Miller School of Medicine, Miami, Florida.
Cynthia LevyDivision of Digestive Health and Liver Diseases, University of Miami Miller School of Medicine, Miami, Florida.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary biliary cholangitis (PBC) is a slowly progressive autoimmune liver disease that, if not promptly and appropriately treated, can lead to significant morbidity, mortality, and a substantial decline in patients' quality of life. Ursodeoxycholic acid is the first-line therapy; however, up to 40% of patients exhibit an inadequate response. For these individuals, 2 US Food and Drug Administration-approved second-line therapies are currently available, which not only demonstrate biochemical efficacy but may also alleviate pruritus as well as fatigue, thereby potentially enhancing quality of life. Ongoing research is focused on developing additional therapeutic options for patients with PBC. This article aims to provide a comprehensive review of existing and emerging PBC treatments that may mitigate disease progression and improve patient outcomes.

Indexed as

farnesoid X receptorperoxisome proliferator-activated receptor agonistPrimary biliary cholangitispruritustherapyursodeoxycholic acid

Identifiers

PMID41626062
PMCPMC12853657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.