Evidence map›Paper›PMID 41626047›Full record

ArticleJournal of surgical case reports2026

High-grade malignant peripheral nerve sheath tumor of the esophagus: a rare case highlighting the diagnostic value of immunohistochemistry.

Miguel Angel Reyna Silva, Maria Samantha Hernandez González, Rubi Carolina Estrada Hernández, Jazmin Montserrat Guzmán Diaz, Alejandro González Ojeda, Clotilde Fuentes Orozco, Maria F Reyes Ponce, German Quiroga Moreno, Sandra Elisea Plascencia Guerrero, Guadalupe Castillo Cardiel and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Miguel Angel Reyna SilvaOncosurgery Department, Specialty Hospital of the Western National Medical Center, Mexican Institute of Social Security, Av. Belisario Domínguez 1000, Belisario Domínguez, 44329 Guadalajara, Jalisco, Mexico.
Maria Samantha Hernandez GonzálezBiomedical Research Unit 2, Specialty Hospital of the Western National Medical Center, Mexican Institute of Social Security, Av. Belisario Domínguez 1000, Belisario Domínguez, 44329 Guadalajara, Jalisco, Mexico.
Rubi Carolina Estrada HernándezBiomedical Research Unit 2, Specialty Hospital of the Western National Medical Center, Mexican Institute of Social Security, Av. Belisario Domínguez 1000, Belisario Domínguez, 44329 Guadalajara, Jalisco, Mexico.
Jazmin Montserrat Guzmán DiazBiomedical Research Unit 2, Specialty Hospital of the Western National Medical Center, Mexican Institute of Social Security, Av. Belisario Domínguez 1000, Belisario Domínguez, 44329 Guadalajara, Jalisco, Mexico.
Alejandro González OjedaColima University, Medical Faculty, Av. Universidad 333, Las Víboras, Colima 28040, Cólima,  México.
Clotilde Fuentes OrozcoBiomedical Research Unit 2, Specialty Hospital of the Western National Medical Center, Mexican Institute of Social Security, Av. Belisario Domínguez 1000, Belisario Domínguez, 44329 Guadalajara, Jalisco, Mexico.
Maria F Reyes PonceGeneral Surgery Department, Specialty Hospital of the Western National Medical Center, Mexican Institute of Social Security, Av. Belisario Domínguez 1000, Belisario Domínguez, 44329 Guadalajara, Jalisco, Mexico.
German Quiroga MorenoBiomedical Research Unit 2, Specialty Hospital of the Western National Medical Center, Mexican Institute of Social Security, Av. Belisario Domínguez 1000, Belisario Domínguez, 44329 Guadalajara, Jalisco, Mexico.
Sandra Elisea Plascencia GuerreroBiomedical Research Unit 2, Specialty Hospital of the Western National Medical Center, Mexican Institute of Social Security, Av. Belisario Domínguez 1000, Belisario Domínguez, 44329 Guadalajara, Jalisco, Mexico.
Guadalupe Castillo CardielBiomedical Research Unit 2, Specialty Hospital of the Western National Medical Center, Mexican Institute of Social Security, Av. Belisario Domínguez 1000, Belisario Domínguez, 44329 Guadalajara, Jalisco, Mexico.
Gabino Cervantes GuevaraDepartment of Well-being and Sustainable Development, Northern University Center, Universidad de Guadalajara, Carretera Federal No. 23, Km. 191, 46200 Colotlán, Jalisco, Mexico.
Enrique Cervantes PérezDepartment of Internal Medicine, Fray Antonio Alcalde Civil Hospital of Guadalajara, St. Hospital 278, Centro Barranquitas, 44200 Guadalajara, Jalisco, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report presents a highly unusual case of a primary high-grade malignant peripheral nerve sheath tumor (MPNST) of esophagus, a neoplasm of extreme rarity, with fewer than twenty histologically confirmed cases reported worldwide to date; detailing the successful management of this tumor through Orringer's transhiatal esophagectomy, complemented by comprehensive histopathologic and immunohistochemical evaluation. Our report emphasizes the crucial the role of immunohistochemistry, specifically the diagnostic value of S100, SOX10, and the exclusion of gastrointestinal stromal tumors markers (DOG1, CD117) in distinguishing MPNST, from morphologically similar esophageal submucosal tumors.

Indexed as

esophagectomyesophagus cancerimmunohistochemistrymalignant peripheral nerve sheath tumorS100 proteinSOX-10 transcription factor

Identifiers

PMID41626047
PMCPMC12860384

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