Evidence map›Paper›PMID 41626029›Full record

ArticleFrontiers in systems neuroscience2025

Event-Related Potentials and executive control deficits in major depression: evidence from the Attention Network Test.

Almira Kustubayeva, Manzura Zholdassova, Altyngul Kamzanova, Zabira Madaliyeva, Aigul Suleimenova, Sultangali Nessipbayev, Gulnur Borbassova, Diana Arman, Erik Nelson, Gerald Matthews

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Article in Frontiers in systems neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Almira Kustubayeva *Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Manzura Zholdassova *Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Altyngul KamzanovaDepartments of Biophysics, Biomedicine, and Neuroscience, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Zabira MadaliyevaDepartment of Psychology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Aigul SuleimenovaRepublican Scientific and Practical Center for Mental Health, Almaty, Kazakhstan.
Sultangali NessipbayevKeruen-Medicus, Almaty, Kazakhstan.
Gulnur BorbassovaDepartment of Psychology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Diana ArmanSchool of Information Technology and Engineering, Kazakh-British Technical University, Almaty, Kazakhstan.
Erik NelsonDepartment of Psychiatry and Behavioral Neuroscience, College of Medicine, University of Cincinnati, Cincinnati, OH, United States.
Gerald Matthews *Department of Psychology, George Mason University, Fairfax, VA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Behavioral and neurological studies suggest that major depressive disorder (MDD) is associated with pervasive deficits in executive control of attention. Research using Event-Related Potentials (ERPs) to investigate attentional impairments in depression has provided mixed results. The current study aimed to clarify abnormalities in ERPs associated with depression through use of the Attention Network Test (ANT) which assesses efficiency of three fundamental brain networks: executive control, alerting, and orienting. Methods: Participants were 93 volunteers. We compared ERP amplitudes in healthy, subsyndromal depression, and MDD groups (31 participants per group) during performance of an extended-duration version of the ANT. Results: Both N100 and P300 ERP amplitudes were generally lower in the MDD group across central-parietal and posterior sites, with medium-to-large effect sizes. There were also significant effects of depression on the ANT indices for executive control and alerting. Further analyses showed that some abnormalities in ERPs were seen in the subsyndromal group and that depression effects were stable across time, despite vigilance decrement. Conclusion: Neurocognitive deficits in depression may relate to depletion of a general attentional resource.

Indexed as

alertingAttention Network TestbiomarkersEvent-Related Potentialsexecutive controlmajor depressive disorder

Identifiers

PMID41626029
PMCPMC12856934

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.