The non-linear association between serum iron and severe impairment of activities of daily living in ischemic stroke patients.

Ranran Bi, Yupeng Shi, Zhongcheng Xie, Xiaochen Liu, Zhenchao Ma, Fang Cui

Abstract read

In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ranran Bi *Department of Rehabilitation Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Yupeng Shi *Department of Rehabilitation, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.

Zhongcheng XieDepartment of Rehabilitation Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Xiaochen LiuDepartment of Rehabilitation Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Zhenchao MaDepartment of Rehabilitation Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Fang CuiDepartment of Rehabilitation Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aims to explore the dose-response relationship and threshold effect of serum iron levels on severe impairment of activities of daily living (ADL) in ischemic stroke patients. Methods: This cross-sectional study included 2,035 ischemic stroke patients admitted to Shanghai East Hospital from 2020 to 2022. Serum iron levels were measured upon admission, and ADL was evaluated using the Barthel Index. Restricted cubic spline regression, multivariate logistic models, and subgroup analysis were employed to analyze the dose-response relationship. Results: A non-linear relationship ( Conclusion: The study found a non-linear relationship between serum iron and severe ADL impairment after ischemic stroke, with an inflection point at about 17.5 μmol/L. Future prospective studies are necessary to clarify this association.

Indexed as

activities of daily livingnon-linear associationserum ironstrokethreshold effect

Identifiers

PMID41626027

DOI10.3389/fneur.2025.1700381

PMCPMC12852888

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.