Evidence map›Paper›PMID 41625977›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Integrated biosynthesis of the lignan (-)-pluviatolide in resting and growing

Ronja Knöfel, Jonas Barsig, Philipp A Bechtold, Cigdem Günes, U Joost Luelf, Vlada B Urlacher

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In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ronja Knöfel *Institute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Jonas Barsig *Institute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Philipp A BechtoldInstitute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Cigdem GünesInstitute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
U Joost LuelfInstitute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Vlada B UrlacherInstitute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lignans exhibit a wide range of useful bioactivities. A key intermediate in their biosynthesis in plants is (-)-pluviatolide, which directs the pathway towards various high-value lignans like (-)-podophyllotoxin - the precursor of the clinically relevant antitumor drugs etoposide and teniposide. In an attempt to develop more sustainable ways for the production of lignans, which are traditionally isolated from plants, we previously established a heterologous biosynthesis of (-)-pluviatolide in

Indexed as

growing cellsmulti-enzyme cascadeplant lignansrecombinant E. coliresting cells

Identifiers

PMID41625977
PMCPMC12855525

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.