Evidence map›Paper›PMID 41625956›Full record

ArticleOptica2025

Enhanced penetration depth in optical coherence tomography and photoacoustic microscopy

David A Miller, Yirui Xu, Robert Highland, Van Tu Nguyen, William J Brown, Guosong Hong, Junjie Yao, Adam Wax

Abstract read
In one paragraph

Article in Optica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Photoacoustic Fingerprinting for Robust Molecular Imaging.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David A MillerDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Yirui XuDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Robert HighlandDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Van Tu NguyenDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
William J BrownLumedica Vision Inc., Durham, NC 27701, USA.
Guosong HongDepartment of Materials Science and Engineering, Stanford University, Stanford, CA 94305 USA.
Junjie YaoDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Adam WaxDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Funding

High-resolution High-speed Photoacoustic and Ultrasound Imaging of SmallVessel Functions in Ischemic StrokeR01NS111039 · NINDS · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2023
$2.7M
Retinal Light Scattering Measurements as a Clinical Biomarker of Alzheimer's DiseaseR01AG072732 · NIA · DUKE UNIVERSITY · PI Adam Wax · 2022 to 2026
$2.4M
Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving AnimalsRF1NS115581 · NINDS · DUKE UNIVERSITY · PI VERKHUSHA, VLADISLAV, YAO, JUNJIE · 2020 to 2020
$2.0M
3D real-time super-resolution cavitation mapping in laser lithotripsy of urinary stone diseaseR01DK139109 · NIDDK · DUKE UNIVERSITY · PI Michael E Lipkin, Junjie Yao · 2024 to 2026
$1.8M
NIA NIH HHS R01 AG072732NIDDK NIH HHS R01 DK139109NINDS NIH HHS R01 NS111039NINDS NIH HHS RF1 NS115581
6 · The paper itself

Abstract

The scattering and absorption of light within biological tissue severely limits the penetration depth of optical imaging techniques. Recently, it has been found that water-soluble, strongly absorbing dye molecules, such as tartrazine, can achieve

Identifiers

PMID41625956
PMCPMC12858289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.