Evidence map›Paper›PMID 41625955›Full record

ArticleIEEE transactions on radiation and plasma medical sciences2025

Improving CTR with the FastIC ASIC for TOF-PET by overcoming SiPM noise with baseline correction.

Afonso Silvério Xavier De Matos Pinto, Nicolaus Kratochwil, Sergio Gómez, David Gascón, Pedro Correia, João Veloso, Emilie Roncali, Ana Luísa Silva, Gerard Ariño-Estrada

Abstract read
In one paragraph

Article in IEEE transactions on radiation and plasma medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Current Status of Cherenkov-Based Gamma Detectors for TOF-PET and Proton Range Verification.IEEE transactions on radiation and plasma medical sciences · 2026
    Article
  2. High-performance dual-ended SiPM readout for TOF-PET with BGO and LYSO:Ce.IEEE transactions on radiation and plasma medical sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Afonso Silvério Xavier De Matos PintoI3N Physics Department (I3N) at the University of Aveiro, Portugal.ORCID 0000-0001-8727-0094
Nicolaus KratochwilDepartment of Biomedical Engineering at UCD.ORCID 0000-0001-5297-1878
Sergio GómezSerra Hunter fellow at Polytechnic University of Catalonia, Spain.ORCID 0000-0002-3064-9834
David GascónDepartment of Fisica at the University of Barcelona, Spain.ORCID 0000-0001-9607-6154
Pedro CorreiaI3N Physics Department (I3N) at the University of Aveiro, Portugal.ORCID 0000-0001-7292-7735
João VelosoI3N Physics Department (I3N) at the University of Aveiro, Portugal.ORCID 0000-0002-7107-7203
Emilie RoncaliDepartment of Biomedical Engineering at UCD.ORCID 0000-0002-2439-1064
Ana Luísa SilvaI3N Physics Department (I3N) at the University of Aveiro, Portugal.ORCID 0000-0002-8363-0109
Gerard Ariño-EstradaDepartment of Biomedical Engineering at UCD.ORCID 0000-0002-6411-191X

Funding

TOF-PET with high-efficiency TlCl crystalsR01EB034062 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Gerard Arino Estrada · 2023 to 2026
$2.5M
NIBIB NIH HHS R01 EB034062
6 · The paper itself

Abstract

Time resolution in time-of-flight positron emission tomography (TOF-PET) has improved significantly over the last decade due to advancements in scintillation materials, photodetectors, and readout electronics, which has increased the signal-to-noise ratio (SNR) compared to conventional PET. Silicon photomultipliers (SiPMs) in TOF-PET detectors are often operated at high bias voltage to improve the time performance at the expense of increasing signal noise. SiPM noise, both correlated and uncorrelated, can cause baseline fluctuations, leading to time-walk effects when a leading edge trigger strategy is used, and thus limiting timing performance. We examined the effect of SiPM baseline fluctuations using the FastIC ASIC, a scalable multichannel readout for fast timing applications. We flagged noisy events by using a comparator signal triggered by dark counts before the actual scintillation event. We tested different classification and correction methods with scintillating crystals and Cherenkov radiators, coupled to analog SiPMs from Broadcom (NUV-MT) and Hamamatsu Photonics. We reduced the coincidence time resolution (CTR) in bismuth germanate 2×2×3 mm

Identifiers

PMID41625955
PMCPMC12858093

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.