ArticleCureus2025
Gestational Neuro-Otological Manifestation Patterns Across Trimesters in Karachi, Pakistan: A Retrospective Cross-Sectional Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of restless legs syndrome in Pakistan: a systematic review and meta-analysis across diverse study populations.BMC neurology · 2026Pooled it
- The ABCDEFG point-of-care ultrasound protocol for acute non-traumatic abdominal pain: a prospective observational study.Journal of ultrasound · 2026Observational
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the prevalence and trimester-specific trends of neuro-otological manifestations among pregnant women attending antenatal care in tertiary care hospitals at Karachi, Pakistan. METHODOLOGY: A prospective, multicenter observational study was conducted from January 2020 to December 2024 at two tertiary hospitals in Karachi. A total of 1,230 pregnant women aged 18-45 years were enrolled through non-probability consecutive sampling. Data were collected using a validated three-part assessment tool encompassing demographic characteristics, otological symptoms, and neurological/vestibular presentations. Statistical analysis was performed using SPSS software version 26 (IBM Corp., Armonk, NY). Chi-square and Fisher's exact tests were applied, with significance defined as
resultsNeuro-otological symptoms were highly prevalent. Otological complaints were reported in 874 (71%) participants, most commonly tinnitus in 390 (31.7%) and ear fullness in 310 (25.2% ). Neurological and vestibular manifestations were observed in 847 (69%), with vertigo (304, 24.7%), headache (260, 21.1%), and dizziness (215, 17.5%) being the most frequent. A significant increase in the frequency of symptoms was noted with advancing gestational age, with the third trimester demonstrating the highest burden across most manifestations (
conclusionsNeuro-otological manifestations are common during pregnancy and exhibit a trimester-dependent rise, peaking in late gestation. Routine screening and early recognition within antenatal care may help prevent misdiagnosis, reduce patient distress, and improve maternal quality of life.
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