ArticleCureus2025
Management of Refractory Infections in a Neonate With Severe Generalized Epidermolysis Bullosa Simplex: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A female neonate, the second child of non-consanguineous parents without a family history of similar disease, was born with erosions and small blisters on the perioral area, oral cavity, and digits, along with a large blister on the buttocks. Epidermolysis bullosa (EB) was suspected, and she was referred to our hospital on the day of birth. Skin biopsy from the right upper arm revealed histopathological clefting at the dermoepidermal junction, and electron microscopy demonstrated intraepidermal blister formation with keratin aggregates. Genetic analysis confirmed a p.Asn176Ile mutation in the KRT5 gene, and, based on the clinical presentation, a diagnosis of severe generalized EB simplex (EBS) (Dowling-Meara (DM) type) was made. On day 5 of life, she developed fever, and blood culture yielded methicillin-susceptible
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