ArticleCureus2025
Comparative Evaluation of Platelet Indices in Clinical and Culture-Positive Neonatal Sepsis: A Prospective Observational Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundNeonatal sepsis is among the significant causes of morbidity and mortality, especially in low- and middle-income countries. Blood culture, the diagnostic gold standard, is limited by delayed results and low sensitivity. Mean platelet volume (MPV) and platelet distribution width (PDW) may offer early, accessible biomarkers.
objectiveThe objective of this study is to evaluate the diagnostic utility of platelet indices, i.e., MPV and PDW, in clinical and culture-positive neonatal sepsis.
methodsA prospective observational study was conducted on 170 neonates with suspected sepsis admitted to the NICU at MGM Hospital, Aurangabad. Participants were categorized into clinical (n = 88) and culture-positive (n = 82) sepsis groups. Platelet parameters were analyzed.
resultsOf the 170 neonates enrolled, 82 (48.2%) had culture-positive sepsis, while 88 (51.8%) were categorized as clinical sepsis. MPV and PDW were significantly higher in both the culture-positive group and the clinical sepsis group.
conclusionMPV and PDW are significantly elevated in both the culture-confirmed neonatal sepsis and the clinical sepsis group. Platelet indices may serve as supportive diagnostic markers in resource-limited settings. Their integration with clinical and laboratory findings could enhance early diagnosis.
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