ArticleCureus2025
Evaluation of the Prognostic Ability of the Antithrombin/Creatinine Ratio in Critically Ill Patients: Comparison With Sequential Organ Failure Assessment (SOFA) Score and Novel Antithrombin-modified SOFA Score.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
purposeThe objective of the study was to evaluate the prognostic ability of the antithrombin/creatinine (AT/Cre) ratio in critically ill patients and compare it with the Sequential Organ Failure Assessment Score (SOFA) score.
methodsThis retrospective cohort study was conducted at two hospitals and included patients admitted to the ICUs between January 2018 and December 2019 who had their AT activity measured within 24 hours of ICU admission. The primary endpoint was mortality at discharge. Statistical analyses included receiver operating characteristic (ROC) curve analysis, K-means clustering, and the Cox proportional hazards model.
resultsThe study included 267 patients, of whom 173 (64.8%) were male. The median age was 69 years. The AT/Cre ratio demonstrated prognostic accuracy of mortality at discharge (AUC: 0.71, cut-off: 53.6) comparable to the SOFA score (AUC: 0.75, cut-off: 8.0). A lower AT/Cre ratio was significantly associated with increased mortality risk in multivariate analyses (hazard ratio (HR): 0.98, 95%CI: 0.98-0.99). When patients were categorized into four clusters, AT/Cre values differed significantly between clusters (p <0.0001), with higher values in clusters with a favorable prognosis.
conclusionThe AT/Cre ratio showed prognostic performance comparable to SOFA, although its incremental value beyond established scores was not evaluated in this study. It is simple to calculate and may be valuable for early risk stratification and treatment decisions.
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