ArticleCureus2025
Management of a Neck Wound in a Premature Infant Using a Bilayered, Living Skin Substitute.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in tissue engineering have enhanced our understanding of wound healing, leading to more effective management of acute and chronic wounds. Bioengineered skin constructs are increasingly favored for their minimal invasiveness and efficacy. Full-thickness neck wounds in premature neonates pose unique reconstructive challenges due to limited treatment options, high infection risk, and the potential for contracture formation. We present a rare case of an infected neck/shoulder wound in a premature infant with immunodeficiency. Following surgical debridement, a bilayered cellular skin substitute, Apligraf (Organogenesis Inc., Canton, USA) was applied to promote wound closure. Given the lack of reports describing the use of Apligraf for complex neck wounds in premature infants, this case demonstrates its potential as a viable reconstructive option in this vulnerable population, achieving early and cosmetically acceptable closure.
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Registered trials
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