ArticleJournal of education and health promotion2025
The impact of type 1 diabetes mellitus on intellectual status: A Mendelian randomization study.
Article in Journal of education and health promotion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundThe status and changes of intelligence are closely related to the treatment and quality of life of patients with type 1 diabetes mellitus (T1DM), but the relationship between the disease and the decline of patients' intelligence and the rise of the risk of intellectual disability (ID) is still uncertain. MATERIALS AND
methodsA Mendelian randomization (MR) analysis was conducted using the inverse-variance-weighted (IVW) method. Additional MR methods, including MR-pleiotropy residual sum and outlier (MR-PRESSO), radial MR, and other extended methods, were employed to address potential confounding factors.
resultsThe MR analysis demonstrated a causal association between T1DM and lower intelligence (
conclusionsThis MR study provided robust evidence that T1DM may lead to a decline in intelligence and an increased risk of ID. Future research, analyzing the mechanism of T1DM occurrence on patients' intellectual status and the characteristics of intelligence changes, would help improve the treatment effectiveness and quality of life of T1DM patients.
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