Evidence map›Paper›PMID 41625609›Full record

ArticleFrontiers in psychiatry2025

Association of personality traits with rumination improvement following cognitive behavioral therapy in major depression: an observational study.

Sachiko Noda, Atsuo Nakagawa, Satoshi Umeda, Mizuki Amano, Waka Nogami, Sakae Ihara, Yuki Kobayashi, Mire Ozawa Kinouchi, Ryo Takemura, Hiroyuki Uchida and 1 more

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In one paragraph

Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sachiko NodaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Atsuo NakagawaDepartment of Neuropsychiatry, St. Marianna University School of Medicine, Kawasaki, Japan.
Satoshi UmedaDepartment of Psychology, Faculty of Letters, Keio University, Tokyo, Japan.
Mizuki AmanoDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Waka NogamiDepartment of Neuropsychiatry, St. Marianna University School of Medicine, Kawasaki, Japan.
Sakae IharaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Yuki KobayashiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Mire Ozawa KinouchiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Ryo TakemuraClinical and Translational Research Center, Keio University Hospital, Tokyo, Japan.
Hiroyuki UchidaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Nariko KatayamaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cognitive behavioral therapy (CBT) is effective for major depressive disorder (MDD), yet individual responses vary. Personality may relate to outcomes, but its role in brooding rumination during CBT remains unclear. This study tested whether baseline personality traits are associated with brooding change in patients with MDD receiving CBT. Methods: In this prospective observational cohort, 75 outpatients were allocated to CBT + treatment-as-usual (TAU) (n=33 baseline; n=30 longitudinal) or TAU alone (n=42; n=38) based on clinical course and preference. The Ruminative Responses Scale (RRS) brooding subscale and the 17-item Grid-Based Hamilton Depression Rating Scale (GRID-HAMD Results: Both groups demonstrated significant within-group improvements. Hedges' g (95% CI): CBT-brooding 0.48 (0.11-0.85), GRID-HAMD Limitations: Nonrandomized allocation, modest sample sizes, and two assessment time points limit precision and power; the eight-predictor model in CBT may be prone to overfitting, so findings are exploratory. Conclusion: In this observational cohort, personality traits, with anxious worrying appearing relevant, were associated with brooding change within CBT, whereas between-group differences were not significant. These hypothesis-generating results require validation in adequately powered randomized trials to inform stratified depression care.

Indexed as

broodingcognitive behavioral therapymajor depressive disorderpersonality traitsrumination

Identifiers

PMID41625609
PMCPMC12855471

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.